Phosphopentose epimerase
| ribulose-phosphate 3-epimerase | |||||||||
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D-ribulose-5-phosphate 3-epimerase dodekamer, Francisella tularensis
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| Identifiers | |||||||||
| EC number | 5.1.3.1 | ||||||||
| CAS number | 9024-20-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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| Search | |
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| PMC | articles |
| PubMed | articles |
| NCBI | proteins |
| Ribulose-phosphate 3 epimerase family | |||||||||
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| Identifiers | |||||||||
| Symbol | Ribul_P_3_epim | ||||||||
| Pfam | PF00834 | ||||||||
| InterPro | IPR000056 | ||||||||
| PROSITE | PDOC00833 | ||||||||
| SCOP | 1rpx | ||||||||
| SUPERFAMILY | 1rpx | ||||||||
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| Available protein structures: | |
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| Pfam | structures |
| PDB | RCSB PDB; PDBe; PDBj |
| PDBsum | structure summary |
Phosphopentose epimerase (also known as ribulose-phosphate 3-epimerase and ribulose 5-phosphate 3-epimerase)(EC 5.1.3.1) is a metalloprotein that catalyzes the interconversion between D-ribulose 5-phosphate and D-xylulose 5-phosphate.
This reversible conversion is required for carbon fixation in plants – through the Calvin cycle – and for the nonoxidative phase of the pentose phosphate pathway. This enzyme has also been implicated in additional pentose and glucuronate interconversions.
In Alcaligenes eutrophus two copies of the gene coding for PPE are known, one is chromosomally encoded P40117, the other one is on a plasmid Q04539. PPE has been found in a wide range of bacteria, archaebacteria, fungi and plants. All the proteins have from 209 to 241 amino acid residues. The enzyme has a TIM barrel structure.
The systematic name of this enzyme class is D-ribulose-5-phosphate 3-epimerase. Other names in common use include
This enzyme participates in 3 metabolic pathways: pentose phosphate pathway, pentose and glucuronate interconversions, and carbon fixation.
The human protein containing this domain is the RPE (gene).
Phosphopentose epimerase belongs to two protein families of increasing hierarchy. This enzyme belongs to the isomerase family, specifically those racemases and epimerases which act on carbohydrates and their derivatives. In addition, the Structural Classification of Proteins database has defined the “ribulose phosphate binding” superfamily for which this epimerase is a member. Other proteins included in this superfamily are 5‘-monophosphate decarboxylase (OMPDC), and 3-keto-l-gulonate 6-phosphate decarboxylase (KGPDC).
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