Picornavirus internal ribosome entry site (IRES)

Picornavirus internal ribosome entry site (IRES)
Predicted secondary structure and sequence conservation of IRES_Picorna
Identifiers
Symbol	IRES_Picorna
Rfam	RF00229
Other data
RNA type	Cis-reg; IRES
Domain(s)	Viruses
GO	0043022
SO	0000243

This family represents the Picornavirus internal ribosome entry site (IRES). IRES elements allow cap and end-independent translation of mRNA in the host cell. It has been found that La autoantigen (La) is required for Coxsackievirus B3 (CVB3) IRES-mediated translation, and it has been suggested that La may be required for the efficient translation of the viral RNA in the pancreas.