Pregnane X receptor

NR1I2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ILG, 1ILH, 1M13, 1NRL, 1SKX, 2O9I, 2QNV, 3CTB, 3HVL, 3R8D, 4J5W, 4J5X, 4NY9, 4S0S, 4S0T, 4XHD, 4X1F, 4X1G, 4XAO, 5A86
Identifiers
Aliases	NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR, nuclear receptor subfamily 1 group I member 2
External IDs	OMIM: 603065 MGI: 1337040 HomoloGene: 40757 GeneCards: NR1I2
Targeted by Drug
17β-estradiol, 3,20-pregnanedione, clotrimazole, lithocholic acid, mifepristone, nifedipine, paclitaxel, phenobarbital, lovastatin
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • transcription coactivator activity • zinc ion binding • metal ion binding • steroid hormone receptor activity • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding • protein binding • drug binding Cellular component • nucleus • nucleoplasm • nuclear body • intermediate filament cytoskeleton Biological process • steroid metabolic process • regulation of transcription, DNA-templated • exogenous drug catabolic process • xenobiotic transport • drug export • transcription, DNA-templated • positive regulation of transcription, DNA-templated • positive regulation of gene expression • xenobiotic metabolic process • transcription initiation from RNA polymerase II promoter • negative regulation of transcription, DNA-templated • signal transduction • steroid hormone mediated signaling pathway • positive regulation of transcription from RNA polymerase II promoter • intracellular receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8856	18171
Ensembl	ENSG00000144852	ENSMUSG00000022809
UniProt	O75469	O54915
RefSeq (mRNA)	NM_033013 NM_003889 NM_022002	NM_001098404 NM_010936
RefSeq (protein)	NP_003880 NP_071285 NP_148934	NP_001091874.1 NP_035066.1 NP_001091874 NP_035066
Location (UCSC)	Chr 3: 119.78 – 119.82 Mb	Chr 16: 38.25 – 38.29 Mb
PubMed search

1ILG, 1ILH, 1M13, 1NRL, 1SKX, 2O9I, 2QNV, 3CTB, 3HVL, 3R8D, 4J5W, 4J5X, 4NY9, 4S0S, 4S0T, 4XHD, 4X1F, 4X1G, 4XAO, 5A86

8856

18171

ENSG00000144852

ENSMUSG00000022809

...
Wikipedia