Prostacyclin synthase

prostaglandin-I synthase
Cartoon diagram of human prostacyclin synthase. Heme group visible at center. From PDB: 2IAG​
Identifiers
EC number	5.3.99.4
CAS number	65802-86-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

PTGIS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3B6H, 2IAG
Identifiers
Aliases	PTGIS, CYP8, CYP8A1, PGIS, PTGI, prostaglandin I2 (prostacyclin) synthase, prostaglandin I2 synthase
External IDs	OMIM: 601699 MGI: 1097156 HomoloGene: 37374 GeneCards: PTGIS
Gene ontology Molecular function • iron ion binding • isomerase activity • metal ion binding • monooxygenase activity • protein binding • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • prostaglandin-I synthase activity Cellular component • cytoplasm • integral component of membrane • endoplasmic reticulum membrane • membrane • caveola • nucleus • endoplasmic reticulum • extracellular space Biological process • prostaglandin metabolic process • positive regulation of execution phase of apoptosis • cellular response to interleukin-6 • lipid metabolic process • icosanoid metabolic process • cyclooxygenase pathway • fatty acid metabolic process • positive regulation of angiogenesis • fatty acid biosynthetic process • negative regulation of nitric oxide biosynthetic process • decidualization • cellular response to interleukin-1 • positive regulation of peroxisome proliferator activated receptor signaling pathway • apoptotic signaling pathway • negative regulation of NF-kappaB transcription factor activity • negative regulation of inflammatory response • oxidation-reduction process • cellular response to hypoxia • embryo implantation • prostaglandin biosynthetic process • NAD biosynthesis via nicotinamide riboside salvage pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5740	19223
Ensembl	ENSG00000124212	ENSMUSG00000017969
UniProt	Q16647	O35074
RefSeq (mRNA)	NM_000961	NM_008968
RefSeq (protein)	NP_000952	NP_032994.1 NP_032994
Location (UCSC)	Chr 20: 49.5 – 49.57 Mb	Chr 2: 167.19 – 167.24 Mb
PubMed search

3B6H, 2IAG

5740

19223

ENSG00000124212

ENSMUSG00000017969

Q16647

O35074

NM_000961

NM_008968

NP_000952

NP_032994.1
NP_032994

Prostaglandin-I synthase (EC 5.3.99.4) also known as prostaglandin I2 (prostacyclin) synthase (PTGIS) or CYP8A1 is an enzyme involved in prostanoid biosynthesis that in humans is encoded by the PTGIS gene. This enzyme belongs to the family of isomerases.

This gene encodes a member of the superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostaglandin H₂ to prostacyclin (prostaglandin I₂), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A₂ contribute to the development of myocardial infarction, stroke, and atherosclerosis.