Prostaglandin EP2 receptor

PTGER2
Identifiers
Aliases	PTGER2, EP2, Prostaglandin E2 receptor, prostaglandin E receptor 2
External IDs	MGI: 97794 HomoloGene: 739 GeneCards: PTGER2
Targeted by Drug
prostaglandin D2, dinoprostone, dinoprost, treprostinil, U46619
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • prostaglandin E receptor activity Cellular component • integral component of membrane • plasma membrane • integral component of plasma membrane • membrane Biological process • response to progesterone • G-protein coupled receptor signaling pathway • response to lipopolysaccharide • regulation of cell proliferation • signal transduction • cellular response to prostaglandin E stimulus • adenylate cyclase-activating G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5732	19217
Ensembl	ENSG00000125384	ENSMUSG00000037759
UniProt	P43116	Q62053
RefSeq (mRNA)	NM_000956	NM_008964
RefSeq (protein)	NP_000947	NP_032990.1 NP_032990
Location (UCSC)	Chr 14: 52.31 – 52.33 Mb	Chr 14: 44.99 – 45 Mb
PubMed search

5732

19217

ENSG00000125384

ENSMUSG00000037759

P43116

Q62053

NM_000956

NM_008964

NP_000947

NP_032990.1
NP_032990

Prostaglandin E₂ receptor 2 (53kDa), also known as EP₂, is a prostaglandin receptor for prostaglandin E2 (PGE₂) encoded by the human gene PTGER2: it is one of four identified EP receptors, the others being EP₁, EP₃, and EP₄, which bind with and mediate cellular responses to PGE₂ and also, but with lesser affinity and responsiveness, certain other prostanoids (see Prostaglandin receptors). EP has been implicated in various physiological and pathological responses.

The PTGER2 gene is located on human chromosome 14 at position p22.1 (i.e. 14q22.1), contains 2 introns and 3 exons, and codes for a G protein coupled receptor (GPCR) of the rhodopsin-like receptor family, Subfamily A14 (see rhodopsin-like receptors#Subfamily A14).

...
Wikipedia