Pyrimidinylpiperazine

Pyrimidinylpiperazine

Names
IUPAC name 2-(piperazin-1-yl)pyrimidine
Identifiers
3D model (Jmol)	Interactive image
ChemSpider	80080 Y
PubChem CID	88747
InChI InChI=1S/C8H12N4/c1-2-10-8(11-3-1)12-6-4-9-5-7-12/h1-3,9H,4-7H2 Y Key: MRBFGEHILMYPTF-UHFFFAOYSA-N Y InChI=1S/C8H12N4/c1-2-10-8(11-3-1)12-6-4-9-5-7-12/h1-3,9H,4-7H2 InChI=1S/C8H12N4/c1-2-10-8(11-3-1)12-6-4-9-5-7-12/h1-3,9H,4-7H2 Key: MRBFGEHILMYPTF-UHFFFAOYSA-N
SMILES n1cccnc1N2CCNCC2
Properties
Chemical formula	C8H12N4
Molar mass	164.21 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Y  (what is YN ?)
Infobox references

1-(2-Pyrimidinyl)piperazine (1-PP, 1-PmP) is a chemical compound and piperazine derivative. It is known to act as an α₂-adrenergic receptor antagonist, and as a 5-HT_1A receptor partial agonist to a much lesser extent. It does not appear to have any significant affinity for the D₂ or α₁-adrenergic receptors.

A number of pyrimidinylpiperazine derivatives are drugs, including:

The anxiolytics are also classified as azapirones due to the azaspirodecanedione moiety in their structures. 1-PP is a common metabolite of most or all of the listed agents.Alnespirone, binospirone, and enilospirone, despite being azapirones, are not piperazines and therefore do not metabolize to 1-PP, and while perospirone and tiospirone are piperazines, they are instead benzothiazole-substituted piperazines and do not metabolize to 1-PP either.