RAGE (receptor)

AGER
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ENS, 2M1K, 2LE9, 4LP5, 2MOV, 3O3U, 2LMB, 4LP4, 4OF5, 4OI8, 4XYN, 2MJW, 2E5E, 2L7U, 3CJJ, 4OFV, 4P2Y, 4OI7, 4YBH,%%s1PWI, 2BJP, 2E5E, 2ENS, 2L7U, 2LE9, 2LMB, 2M1K, 2MJW, 2MOV, 3CJJ, 3O3U, 4LP4, 4LP5, 4OF5, 4OFV, 4OI7, 4OI8, 4P2Y, 4XYN
Identifiers
Aliases	AGER, Ager, RAGE, SCARJ1, advanced glycosylation end product-specific receptor, advanced glycosylation end-product specific receptor
External IDs	MGI: 893592 HomoloGene: 883 GeneCards: AGER
Gene ontology Molecular function • S100 protein binding • protein binding • identical protein binding • transmembrane signaling receptor activity • receptor activity • advanced glycation end-product binding • heparin binding Cellular component • integral component of membrane • membrane • integral component of plasma membrane • extracellular region • fibrillar center • plasma membrane • cell junction Biological process • negative regulation of interleukin-10 production • positive regulation of interleukin-12 production • cell surface receptor signaling pathway • response to wounding • positive regulation of NF-kappaB transcription factor activity • positive regulation of dendritic cell differentiation • innate immune response • inflammatory response • regulation of T cell mediated cytotoxicity • regulation of CD4-positive, alpha-beta T cell activation • positive regulation of activated T cell proliferation • negative regulation of advanced glycation end-product receptor activity • protein localization to membrane • positive regulation of JUN kinase activity • regulation of DNA binding • induction of positive chemotaxis • regulation of inflammatory response • response to hypoxia • astrocyte development • neuron projection development • negative regulation of connective tissue replacement involved in inflammatory response wound healing • positive regulation of monocyte chemotactic protein-1 production Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	177	11596
Ensembl	ENSG00000237405 ENSG00000206320 ENSG00000231268 ENSG00000234729 ENSG00000229058 ENSG00000204305 ENSG00000230514	ENSMUSG00000015452
UniProt	Q15109	Q62151
RefSeq (mRNA)	NM_001136 NM_001206929 NM_001206932 NM_001206934 NM_001206936 NM_001206940 NM_001206954 NM_001206966 NM_172197	NM_001271422 NM_001271423 NM_001271424 NM_007425
RefSeq (protein)	NP_001127 NP_001193858 NP_001193861 NP_001193863 NP_001193865 NP_001193869 NP_001193883 NP_001193895 NP_751947	NP_001258351 NP_001258352 NP_001258353 NP_031451
Location (UCSC)	Chr 6: 32.18 – 32.18 Mb	Chr 17: 34.6 – 34.6 Mb
PubMed search

2ENS, 2M1K, 2LE9, 4LP5, 2MOV, 3O3U, 2LMB, 4LP4, 4OF5, 4OI8, 4XYN, 2MJW, 2E5E, 2L7U, 3CJJ, 4OFV, 4P2Y, 4OI7, 4YBH,%%s1PWI, 2BJP, 2E5E, 2ENS, 2L7U, 2LE9, 2LMB, 2M1K, 2MJW, 2MOV, 3CJJ, 3O3U, 4LP4, 4LP5, 4OF5, 4OFV, 4OI7, 4OI8, 4P2Y, 4XYN

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