RASGRF1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2IJE

Identifiers

RASGRF1, CDC25, CDC25L, GNRP, GRF1, GRF55, H-GRF55, PP13187, ras-GRF1, Ras protein specific guanine nucleotide releasing factor 1

External IDs

Genetically Related Diseases

Gene ontology
Molecular function	• Rho guanyl-nucleotide exchange factor activity • guanyl-nucleotide exchange factor activity • glutamate receptor binding • Ras guanyl-nucleotide exchange factor activity
Cellular component	• cytosol • growth cone • neuron projection • plasma membrane
Biological process	• intracellular signal transduction • MAPK cascade • regulation of Rho protein signal transduction • positive regulation of GTPase activity • signal transduction • regulation of Rac protein signal transduction • regulation of synaptic plasticity • long-term memory • regulation of Ras protein signal transduction • regulation of neuronal synaptic plasticity • neuron projection development • regulation of NMDA receptor activity • activation of GTPase activity • cell proliferation • small GTPase mediated signal transduction • positive regulation of Ras protein signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5923


19417


ENSG00000058335


ENSMUSG00000032356


Q13972


P27671

RefSeq (mRNA)


NM_001145648 NM_002891 NM_153815


NM_001039655 NM_011245

RefSeq (protein)


NP_001139120 NP_002882 NP_722522


NP_035375.1 NP_001034744 NP_035375

Location (UCSC)

PubMed search

Ras protein-specific guanine nucleotide-releasing factor 1 is a protein in humans that is encoded by the RASGRF1 gene.

The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein.