RASGRP1

RASGRP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4L9M, 4L9U
Identifiers
Aliases	RASGRP1, CALDAG-GEFI, CALDAG-GEFII, RASGRP, V, hRasGRP1, RAS guanyl releasing protein 1
External IDs	MGI: 1314635 HomoloGene: 4195 GeneCards: RASGRP1
Genetically Related Diseases
rheumatoid arthritis, type 2 diabetes mellitus, type 1 diabetes mellitus
Gene ontology Molecular function • calcium ion binding • protein homodimerization activity • phosphatidylcholine binding • zinc ion binding • phosphatidylserine binding • metal ion binding • diacylglycerol binding • lipid binding • Ras guanyl-nucleotide exchange factor activity • guanyl-nucleotide exchange factor activity Cellular component • cytoplasm • Golgi apparatus • endoplasmic reticulum membrane • membrane • mast cell granule • Golgi membrane • endoplasmic reticulum • cytosol • plasma membrane • intracellular Biological process • cell differentiation • positive regulation of protein phosphorylation • positive regulation of T cell differentiation in thymus • intracellular signal transduction • regulation of phospholipase C activity • positive regulation of MAP kinase activity • positive regulation of natural killer cell differentiation • inflammatory response to antigenic stimulus • vesicle transport along microtubule • activation of GTPase activity • regulation of GTPase activity • cytokine production • positive regulation of Ras protein signal transduction • positive regulation of natural killer cell activation • positive regulation of JNK cascade • secretory granule localization • MAPK cascade • regulation of phosphatidylinositol 3-kinase signaling • positive regulation of GTPase activity • positive regulation of interferon-gamma secretion • positive regulation of granulocyte macrophage colony-stimulating factor production • protein oligomerization • positive regulation of ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of tumor necrosis factor production • Ras protein signal transduction • mast cell degranulation • regulation of p38MAPK cascade • positive regulation of natural killer cell mediated cytotoxicity • signal transduction • small GTPase mediated signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10125	19419
Ensembl	ENSG00000172575	ENSMUSG00000027347
UniProt	O95267	Q9Z1S3
RefSeq (mRNA)	NM_001128602 NM_001306086 NM_005739	NM_011246
RefSeq (protein)	NP_001122074 NP_001293015 NP_005730	NP_035376.1 NP_035376
Location (UCSC)	Chr 15: 38.49 – 38.57 Mb	Chr 2: 117.28 – 117.34 Mb
PubMed search

4L9M, 4L9U

10125

19419

ENSG00000172575

ENSMUSG00000027347

O95267

Q9Z1S3

NM_001128602
NM_001306086
NM_005739

NM_011246

NP_001122074
NP_001293015
NP_005730

NP_035376.1
NP_035376

RAS guanyl-releasing protein 1 is a protein that in humans is encoded by the RASGRP1 gene.

RAS guanyl nucleotide-releasing protein (RASGRP) is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation.

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