RASGRP2

RASGRP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MA2
Identifiers
Aliases	RASGRP2, CALDAG-GEFI, CDC25L, RAS guanyl releasing protein 2
External IDs	MGI: 1333849 HomoloGene: 4250 GeneCards: RASGRP2
Gene location (Human) Chr. Chromosome 11 (human) Band No data available Start 64,726,911 bp End 64,745,456 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band No data available Start 6,399,340 bp End 6,415,216 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • metal ion binding • diacylglycerol binding • lipid binding • guanyl-nucleotide exchange factor activity Cellular component • cytoplasm • cytosol • cell projection • membrane • plasma membrane • synapse • ruffle membrane • cell junction • neuron projection Biological process • cellular response to calcium ion • intracellular signal transduction • small GTPase mediated signal transduction • positive regulation of GTPase activity • regulation of cell growth • Ras protein signal transduction • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10235	19395
Ensembl	ENSG00000068831	n/a
UniProt	Q7LDG7	Q9QUG9
RefSeq (mRNA)	NM_001098670 NM_001098671 NM_005825 NM_153819 NM_001318398	NM_011242
RefSeq (protein)	NP_001092140 NP_001092141 NP_001305327 NP_722541	NP_035372
Location (UCSC)	Chr 11: 64.73 – 64.75 Mb	Chr 11: 6.4 – 6.42 Mb
PubMed search

2MA2

10235

19395

ENSG00000068831

n/a

Q7LDG7

Q9QUG9

NM_001098670
NM_001098671
NM_005825
NM_153819
NM_001318398

NM_011242

NP_001092140
NP_001092141
NP_001305327
NP_722541

NP_035372

RAS guanyl-releasing protein 2 is a protein that in humans is encoded by the RASGRP2 gene.

The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Two alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been reported.

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