RE1-silencing transcription factor

REST
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CZY
Identifiers
Aliases	REST, Rest, 2610008J04Rik, AA407358, NRSF, XBR, REST4, WT6, RE1 silencing transcription factor
External IDs	MGI: 104897 HomoloGene: 4099 GeneCards: REST
Gene ontology Molecular function • DNA binding • outward rectifier potassium channel activity • core promoter binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • transcription factor binding • metal ion binding • core promoter sequence-specific DNA binding • protein binding • nucleic acid binding • transcription regulatory region DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • histone deacetylase activity • chromatin binding • transcription factor activity, sequence-specific DNA binding Cellular component • cytosol • nucleoplasm • transcriptional repressor complex • nucleus Biological process • cellular response to electrical stimulus • negative regulation of dense core granule biogenesis • negative regulation of insulin secretion • negative regulation of neuron differentiation • regulation of transcription from RNA polymerase II promoter • negative regulation of cortisol biosynthetic process • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • negative regulation of gene expression • transcription, DNA-templated • negative regulation of amniotic stem cell differentiation • positive regulation of transcription, DNA-templated • negative regulation of mesenchymal stem cell differentiation • negative regulation by host of viral transcription • histone H4 deacetylation • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • cellular response to drug • cellular response to glucocorticoid stimulus • negative regulation of calcium ion-dependent exocytosis • hematopoietic progenitor cell differentiation • positive regulation of apoptotic process • positive regulation of transcription from RNA polymerase II promoter • negative regulation of cell proliferation • negative regulation of aldosterone biosynthetic process • negative regulation of transcription, DNA-templated • cardiac muscle cell myoblast differentiation • negative regulation of neurogenesis • potassium ion transmembrane transport • regulation of transcription, DNA-templated Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5978	19712
Ensembl	ENSG00000084093	ENSMUSG00000029249
UniProt	Q13127	Q8VIG1
RefSeq (mRNA)	NM_001193508 NM_005612	NM_011263
RefSeq (protein)	NP_001180437 NP_005603	NP_035393.2 NP_035393
Location (UCSC)	Chr 4: 56.91 – 56.94 Mb	Chr 5: 77.27 – 77.29 Mb
PubMed search

2CZY

5978

19712

ENSG00000084093

ENSMUSG00000029249

Q13127

Q8VIG1

NM_001193508
NM_005612

NM_011263

NP_001180437
NP_005603

NP_035393.2
NP_035393

RE1-Silencing Transcription factor (REST), also known as Neuron-Restrictive Silencer Factor (NRSF), is a protein which in humans is encoded by the REST gene, and acts as a transcriptional repressor. REST is expressly involved in the repression of neural genes in non-neuronal cells. Many genetic disorders have been tied to alterations in the REST expression pattern, including colon and small-cell lung carcinomas found with truncated versions of REST. In addition to these cancers, defects in REST have also been attributed a role in Huntington Disease, neuroblastomas, and the effects of epileptic seizures and ischemia.

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