RIG-I

DDX58
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LWD, 2LWE, 2QFB, 2QFD, 2RMJ, 2YKG, 3LRN, 3LRR, 3NCU, 3OG8, 3ZD6, 3ZD7, 4AY2, 4BPB, 4NQK, 4ON9, 4P4H, 5E3H, 5F98, 5F9F, 5F9H
Identifiers
Aliases	DDX58, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, RIGI, RLR-1, SGMRT2, RIG-I, DEXD/H-box helicase 58
External IDs	MGI: 2442858 HomoloGene: 32215 GeneCards: DDX58
Gene ontology Molecular function • nucleotide binding • helicase activity • zinc ion binding • metal ion binding • protein binding • single-stranded RNA binding • identical protein binding • RNA binding • double-stranded RNA binding • double-stranded DNA binding • hydrolase activity • ATP binding • nucleic acid binding • ubiquitin protein ligase binding Cellular component • cytoplasm • cell projection • membrane • bicellular tight junction • plasma membrane • ruffle membrane • cell junction • actin cytoskeleton • cytoskeleton • cytosol Biological process • regulation of cell migration • response to exogenous dsRNA • positive regulation of interferon-alpha production • immune system process • response to virus • positive regulation of sequence-specific DNA binding transcription factor activity • positive regulation of transcription factor import into nucleus • cytoplasmic pattern recognition receptor signaling pathway in response to virus • positive regulation of gene expression • positive regulation of granulocyte macrophage colony-stimulating factor production • defense response to virus • positive regulation of interleukin-8 production • positive regulation of interleukin-6 production • negative regulation of type I interferon production • detection of virus • viral process • innate immune response • positive regulation of transcription from RNA polymerase II promoter • RIG-I signaling pathway • regulation of type III interferon production • positive regulation of defense response to virus by host • positive regulation of interferon-beta production • protein deubiquitination Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23586	230073
Ensembl	ENSG00000107201	ENSMUSG00000040296
UniProt	O95786	Q6Q899
RefSeq (mRNA)	NM_014314	NM_172689
RefSeq (protein)	NP_055129	NP_766277.3 NP_766277
Location (UCSC)	Chr 9: 32.46 – 32.53 Mb	Chr 4: 40.2 – 40.24 Mb
PubMed search

2LWD, 2LWE, 2QFB, 2QFD, 2RMJ, 2YKG, 3LRN, 3LRR, 3NCU, 3OG8, 3ZD6, 3ZD7, 4AY2, 4BPB, 4NQK, 4ON9, 4P4H, 5E3H, 5F98, 5F9F, 5F9H

23586

230073

ENSG00000107201

ENSMUSG00000040296

...
Wikipedia