RhoG

RHOG
Identifiers
Aliases	RHOG, ARHG, RhoG, ras homolog family member G
External IDs	MGI: 1928370 HomoloGene: 68196 GeneCards: RHOG
Gene ontology Molecular function • nucleotide binding • GTP binding • protein binding • GTPase activity Cellular component • cytosol • endoplasmic reticulum membrane • membrane • focal adhesion • plasma membrane • extracellular exosome • secretory granule membrane • intracellular Biological process • activation of GTPase activity • platelet activation • positive regulation of transcription, DNA-templated • Rho protein signal transduction • positive regulation of cell proliferation • regulation of ruffle assembly • cell chemotaxis • Rac protein signal transduction • regulation of small GTPase mediated signal transduction • actin cytoskeleton organization • small GTPase mediated signal transduction • neutrophil degranulation • positive regulation of protein localization to plasma membrane Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	391	56212
Ensembl	ENSG00000177105	ENSMUSG00000073982
UniProt	P84095	P84096
RefSeq (mRNA)	NM_001665	NM_019566
RefSeq (protein)	NP_001656	NP_062512
Location (UCSC)	Chr 11: 3.83 – 3.84 Mb	Chr 7: 102.24 – 102.26 Mb
PubMed search

391

56212

ENSG00000177105

ENSMUSG00000073982

P84095

P84096

NM_001665

NM_019566

NP_001656

NP_062512

RhoG (Ras homology Growth-related) (or ARGH) is a small (~21 kDa) monomeric GTP-binding protein (G protein), and is an important component of many intracellular signalling pathways. It is a member of the Rac subfamily of the Rho family of small G proteins and is encoded by the gene RHOG.

RhoG was first identified as a coding sequence upregulated in hamster lung fibroblasts upon stimulation with serum. Expression of RhoG in mammals is widespread and studies of its function have been carried out in fibroblasts,leukocytes,neuronal cells,endothelial cells and HeLa cells. RhoG belongs to the Rac subgroup and emerged as a consequence of retroposition in early vertebrates. RhoG shares a subset of common binding partners with Rac, Cdc42 and RhoU/V members but a major specificity is its inability to bind to CRIB domain proteins such as PAKs.

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Wikipedia