Rosa Beddington
| Rosa Beddington | |
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| Born | Rosa Susan Penelope Beddington 23 March 1956 Hampshire, England, UK |
| Died | 18 May 2001 (aged 45) Great Tew, Oxfordshire, England, UK |
| Nationality | United Kingdom |
| Fields | Developmental biology |
| Institutions |
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| Alma mater | Brasenose College, Oxford (BA, PhD) |
| Thesis | Studies on cell fate and cell potency in the postimplantation mammalian embryo (1981) |
| Doctoral advisor |
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| Known for | Anterior-posterior patterning in mammalian embryos |
| Notable awards |
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| Spouse | Robin Denniston |
Rosa Susan Penelope Beddington FRS (23 March 1956 – 18 May 2001) was a British biologist whose career had a major impact on developmental biology.
Beddington was born on 23 March 1956, the second daughter of Roy and Anna Beddington (née Griffith). She attended Sherborne School for Girls and then attended Brasenose College, Oxford; from 1974, obtaining a First in Physiological Sciences in 1977. Beddington embarked on the study of anterior-posterior axial patterning in mammalian embryos, beginning with her doctoral thesis entitled, "Studies on cell fate and cell potency in the postimplantation mammalian embryo" supervised by Richard Gardner and Virginia Papaioannou, and was awarded a DPhil in 1981.
Beddington published numerous high-profile papers in her relatively short career (several important papers being published posthumously). She worked extensively on the developmental genetics of axial patterning, germ layer specification, and other phenomena of gastrulation in mammals, including demonstrating that the node is the organizer in mammals. Her technical contributions to experimental embryology include surgical re-implantation into the uterus to extend the time an experimentally manipulated embryo can be cultured and the use of a transgenic marker (beta-galactosidase) to identify transplant versus host tissue in experimental embryos.
While a fellow at the Imperial Cancer Research Fund, (now Cancer Research UK) laboratory in Oxford, Beddington and Elizabeth Robertson recognised the potential of embryonic stem cells for the study of genetic manipulation after demonstrating the ability of these cells to colonise developing embryos.
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