S-methyltransferase

TPMT
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BZG, 2H11
Identifiers
Aliases	TPMT, entrez:7172, TPMTD, thiopurine S-methyltransferase
External IDs	OMIM: 187680 MGI: 98812 HomoloGene: 313 GeneCards: TPMT
Gene location (Human) Chr. Chromosome 6 (human) Band 6p22.3 Start 18,128,311 bp End 18,155,074 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13 A5|13 24.5 cM Start 47,022,482 bp End 47,044,737 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • S-adenosylmethionine-dependent methyltransferase activity • transferase activity • methyltransferase activity • thiopurine S-methyltransferase activity Cellular component • cytosol • extracellular exosome • cytoplasm Biological process • nucleobase-containing compound metabolic process • methylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7172	22017
Ensembl	ENSG00000137364	ENSMUSG00000021376
UniProt	P51580	O55060
RefSeq (mRNA)	NM_000367 NM_001346817 NM_001346818	NM_016785
RefSeq (protein)	NP_000358 NP_001333746 NP_001333747	NP_058065
Location (UCSC)	Chr 6: 18.13 – 18.16 Mb	Chr 6: 47.02 – 47.04 Mb
PubMed search

thiopurine S-methyltransferase
Identifiers
EC number	2.1.1.67
CAS number	67339-09-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Search
PMC	articles
PubMed	articles
NCBI	proteins

2BZG, 2H11

7172

22017

ENSG00000137364

ENSMUSG00000021376

P51580

O55060

NM_000367
NM_001346817
NM_001346818

NM_016785

NP_000358
NP_001333746
NP_001333747

NP_058065

Thiopurine methyltransferase or thiopurine S-methyltransferase (TPMT) is an enzyme that in humans is encoded by the TPMT gene. A pseudogene for this locus is located on chromosome 18q.

Thiopurine methyltransferase methylates thiopurine compounds. The methyl donor is S-adenosyl-L-methionine, which is converted to S-adenosyl-L-homocysteine. This enzyme metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct.

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