SETDB1

SETDB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3DLM, 4X3S, 5KE2
Identifiers
Aliases	SETDB1, ESET, H3-K9-HMTase4, KG1T, KMT1E, TDRD21, SET domain bifurcated 1
External IDs	MGI: 1934229 HomoloGene: 32157 GeneCards: SETDB1
Gene location (Human) Chr. Chromosome 1 (human) Band No data available Start 150,926,263 bp End 150,964,744 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band No data available Start 95,323,525 bp End 95,357,202 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • methyltransferase activity • transferase activity • DNA binding • promoter-specific chromatin binding • zinc ion binding • histone-lysine N-methyltransferase activity • metal ion binding • protein binding • chromatin binding Cellular component • intracellular membrane-bounded organelle • plasma membrane • nucleoplasm • chromosome • nucleus • cytosol Biological process • regulation of transcription, DNA-templated • positive regulation of methylation-dependent chromatin silencing • response to vitamin • transcription, DNA-templated • methylation • histone lysine methylation • Ras protein signal transduction • response to ethanol • covalent chromatin modification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9869	84505
Ensembl	ENSG00000143379	ENSMUSG00000015697
UniProt	Q15047	O88974
RefSeq (mRNA)	NM_001145415 NM_001243491 NM_012432	NM_001163641 NM_001163642 NM_018877
RefSeq (protein)	NP_001138887 NP_001230420 NP_036564	n/a
Location (UCSC)	Chr 1: 150.93 – 150.96 Mb	Chr 1: 95.32 – 95.36 Mb
PubMed search

3DLM, 4X3S, 5KE2

9869

84505

ENSG00000143379

ENSMUSG00000015697

Q15047

O88974

NM_001145415
NM_001243491
NM_012432

NM_001163641
NM_001163642
NM_018877

NP_001138887
NP_001230420
NP_036564

n/a

Histone-lysine N-methyltransferase SETDB1 is an enzyme that in humans is encoded by the SETDB1 gene.

The SET domain is a highly conserved, approximately 150-amino acid motif implicated in the modulation of chromatin structure. It was originally identified as part of a larger conserved region present in the Drosophila Trithorax protein and was subsequently identified in the Drosophila Su(var)3-9 and 'Enhancer of zeste' proteins, from which the acronym SET is derived. Studies have suggested that the SET domain may be a signature of proteins that modulate transcriptionally active or repressed chromatin states through chromatin remodeling activities.

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