SMAD1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1KHU, 2LAW, 2LAX, 2LAY, 2LAZ, 2LB0, 2LB1, 3Q47, 3Q4A

Identifiers

Aliases

SMAD1, BSP-1, BSP1, JV4-1, JV41, MADH1, MADR1, SMAD family member 1

External IDs

OMIM: 601595 MGI: 109452 HomoloGene: 21196 GeneCards: SMAD1

Gene ontology
Molecular function	• DNA binding • co-SMAD binding • signal transducer activity, downstream of receptor • protein homodimerization activity • I-SMAD binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • metal ion binding • transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity • RNA polymerase II core promoter proximal region sequence-specific DNA binding • protein binding • identical protein binding • protein heterodimerization activity • protein kinase binding • RNA polymerase II core promoter sequence-specific DNA binding • sequence-specific DNA binding • DEAD/H-box RNA helicase binding • primary miRNA binding
Cellular component	• cytoplasm • integral component of membrane • SMAD protein complex • cytosol • transcription factor complex • intracellular • nucleoplasm • protein complex • nuclear inner membrane • nucleus
Biological process	• positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus • SMAD protein complex assembly • ureteric bud development • regulation of transcription, DNA-templated • SMAD protein signal transduction • embryonic pattern specification • regulation of transcription from RNA polymerase II promoter • cellular response to organic cyclic compound • hindbrain development • cellular response to BMP stimulus • cardiac muscle cell proliferation • BMP signaling pathway • transcription, DNA-templated • MAPK cascade • protein phosphorylation • gamete generation • cartilage development • positive regulation of gene expression • positive regulation of osteoblast differentiation • positive regulation of cartilage development • primary miRNA processing • mesodermal cell fate commitment • inflammatory response • bone development • transforming growth factor beta receptor signaling pathway • midbrain development • signal transduction • negative regulation of cell proliferation • positive regulation of transcription from RNA polymerase II promoter • osteoblast fate commitment • homeostatic process • transcription from RNA polymerase II promoter • positive regulation of pri-miRNA transcription from RNA polymerase II promoter • protein deubiquitination
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


4086


17125

Ensembl


ENSG00000170365


ENSMUSG00000031681

UniProt


Q15797


P70340

RefSeq (mRNA)


NM_001003688 NM_005900


NM_008539

RefSeq (protein)


NP_001003688 NP_005891


NP_032565.2 NP_032565

Location (UCSC)

Chr 4: 145.48 – 145.56 Mb

Chr 8: 79.34 – 79.4 Mb

PubMed search

1KHU, 2LAW, 2LAX, 2LAY, 2LAZ, 2LB0, 2LB1, 3Q47, 3Q4A

NM_001003688
NM_005900

NM_008539

NP_001003688
NP_005891

NP_032565.2
NP_032565

...
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