SMARCA4

SMARCA4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GRC, 2H60, 3UVD, 5DKD, 5EA1
Identifiers
Aliases	SMARCA4, BAF190, BAF190A, BRG1, MRD16, RTPS2, SNF2, SNF2L4, SNF2LB, SWI2, hSNF2b, CSS4, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
External IDs	MGI: 88192 HomoloGene: 135927 GeneCards: SMARCA4
Gene ontology Molecular function • RNA polymerase II distal enhancer sequence-specific DNA binding • nucleotide binding • RNA polymerase II transcription coactivator activity • DNA-dependent ATPase activity • RNA polymerase I CORE element sequence-specific DNA binding • helicase activity • transcription corepressor activity • protein N-terminus binding • transcription coactivator activity • histone binding • p53 binding • transcription factor binding • Tat protein binding • DNA polymerase binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • hydrolase activity, acting on acid anhydrides • ATPase activity • protein binding • androgen receptor binding • lysine-acetylated histone binding • nucleosomal DNA binding • hydrolase activity • ATP binding Cellular component • nBAF complex • membrane • SWI/SNF complex • nucleoplasm • protein complex • npBAF complex • nucleolus • nuclear chromatin • nucleus • extracellular space Biological process • positive regulation of glucose mediated signaling pathway • chromatin remodeling • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter • negative regulation of androgen receptor signaling pathway • positive regulation of sequence-specific DNA binding transcription factor activity • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • nervous system development • ATP-dependent chromatin remodeling • positive regulation of transcription, DNA-templated • positive regulation of Wnt signaling pathway • negative regulation of G1/S transition of mitotic cell cycle • negative regulation of cell growth • positive regulation of pri-miRNA transcription from RNA polymerase II promoter • positive regulation by host of viral transcription • neural retina development • negative regulation of transcription from RNA polymerase II promoter during mitotic cell cycle • positive regulation of transcription from RNA polymerase II promoter • beta-catenin-TCF complex assembly • covalent chromatin modification • nucleosome disassembly • negative regulation of transcription, DNA-templated • chromatin organization • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6597	20586
Ensembl	ENSG00000127616	ENSMUSG00000032187
UniProt	P51532 Q9HBD4	Q3TKT4
RefSeq (mRNA)	NM_001128844 NM_001128845 NM_001128846 NM_001128847 NM_001128848 NM_001128849 NM_003072	NM_001174078 NM_001174079 NM_011417
RefSeq (protein)	NP_001122316 NP_001122317 NP_001122318 NP_001122319 NP_001122320 NP_001122321 NP_003063 NP_001122321.1	NP_001167549.1 NP_001167550.1 NP_035547.2 NP_001167549 NP_001167550 NP_035547
Location (UCSC)	Chr 19: 10.96 – 11.07 Mb	Chr 9: 21.62 – 21.7 Mb
PubMed search

2GRC, 2H60, 3UVD, 5DKD, 5EA1

6597

20586

ENSG00000127616

ENSMUSG00000032187

P51532
Q9HBD4

Q3TKT4

NM_001128849
NM_003072

NM_001174078
NM_001174079
NM_011417

NP_001122321
NP_003063
NP_001122321.1

NP_035547

Transcription activator BRG1 also known as ATP-dependent helicase SMARCA4 is a protein that in humans is encoded by the SMARCA4 gene.

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Wikipedia