SMOC2

SMOC2
Identifiers
Aliases	SMOC2, DTDP1, MST117, MSTP117, MSTP140, SMAP2, bA270C4A.1, bA37D8.1, dJ421D16.1, SPARC related modular calcium binding 2
External IDs	MGI: 1929881 HomoloGene: 11150 GeneCards: SMOC2
Gene ontology Molecular function • calcium ion binding • glycosaminoglycan binding • heparin binding • metal ion binding Cellular component • proteinaceous extracellular matrix • extracellular region • basement membrane • interstitial matrix Biological process • extracellular matrix organization • signal transduction • positive regulation of cell-substrate adhesion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	64094	64074
Ensembl	ENSG00000112562	ENSMUSG00000023886
UniProt	Q9H3U7	Q8CD91
RefSeq (mRNA)	NM_001166412 NM_022138	NM_022315
RefSeq (protein)	NP_001159884 NP_071421	NP_071710
Location (UCSC)	Chr 6: 168.44 – 168.67 Mb	Chr 17: 14.28 – 14.4 Mb
PubMed search

64094

64074

ENSG00000112562

ENSMUSG00000023886

Q9H3U7

Q8CD91

NM_001166412
NM_022138

NM_022315

NP_001159884
NP_071421

NP_071710

SPARC-related modular calcium-binding protein 2 is a protein that in humans is encoded by the SMOC2 gene.

This gene has been shown mutated in clinical cases of major dental developmental defects.

Brachycephalic dogs show a shortening of the snout along with a widening of the hard hard palate. This skull form is highly associated with breathing distress and eye trauma. The skull form is correlated with a variation in the SMOC2 gene.

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Wikipedia