SNX5

SNX5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SYS
Identifiers
Aliases	SNX5, sorting nexin 5
External IDs	MGI: 1916428 HomoloGene: 40944 GeneCards: SNX5
Gene ontology Molecular function • dynactin binding • protein binding • phosphatidylinositol binding • protein heterodimerization activity • lipid binding • cadherin binding Cellular component • cytoplasm • endosome • cell projection • early endosome membrane • retromer, tubulation complex • membrane • ruffle • extrinsic component of cytoplasmic side of plasma membrane • plasma membrane • extrinsic component of endosome membrane • tubular endosome • retromer complex • early endosome • phagocytic cup • cytoplasmic vesicle membrane • macropinocytic cup • cytoplasmic vesicle • cytosol • intracellular Biological process • endocytosis • vesicle organization • retrograde transport, endosome to Golgi • transport • protein transport • pinocytosis • intracellular protein transport • regulation of macroautophagy Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	27131	69178
Ensembl	ENSG00000089006	ENSMUSG00000027423
UniProt	Q9Y5X3 Q5QPE4	Q9D8U8
RefSeq (mRNA)	NM_152227 NM_001282454 NM_014426	NM_001199188 NM_024225
RefSeq (protein)	NP_001269383 NP_055241 NP_689413	NP_001186117 NP_077187
Location (UCSC)	Chr 20: 17.94 – 17.97 Mb	Chr 2: 144.25 – 144.27 Mb
PubMed search

1SYS

27131

69178

ENSG00000089006

ENSMUSG00000027423

Q9Y5X3
Q5QPE4

Q9D8U8

NM_152227
NM_001282454
NM_014426

NM_001199188
NM_024225

NP_001269383
NP_055241
NP_689413

NP_001186117
NP_077187

Sorting nexin-5 is a protein that in humans is encoded by the SNX5 gene.

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein is a component of the mammalian retromer complex, which facilitates cargo retrieval from endosomes to the trans-Golgi network. It has also been shown to bind to the Fanconi anemia, complementation group A protein. This gene results in two transcript variants encoding the same protein.

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