SORL1

SORL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DM4, 3G2S, 3G2T, 3WSX, 3WSY, 3WSZ
Identifiers
Aliases	SORL1, sortilin-related receptor, L(DLR class) A repeats containing, C11orf32, LR11, LRP9, SORLA, SorLA-1, gp250, sortilin related receptor 1
External IDs	MGI: 1202296 HomoloGene: 2336 GeneCards: SORL1
Gene location (Human) Chr. Chromosome 11 (human) Band 11q24.1 Start 121,452,203 bp End 121,633,693 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A5.1 Start 41,964,720 bp End 42,124,297 bp
Gene ontology Molecular function • amyloid-beta binding • low-density lipoprotein particle binding • protein binding • ADP-ribosylation factor binding • transmembrane signaling receptor activity Cellular component • integral component of membrane • recycling endosome • endosome • Golgi apparatus • membrane • Golgi cisterna • integral component of plasma membrane • extracellular region • trans-Golgi network • early endosome • endoplasmic reticulum • low-density lipoprotein particle • nuclear envelope lumen • extracellular exosome • Golgi membrane • extracellular space • endosome membrane Biological process • negative regulation of tau-protein kinase activity • protein targeting • steroid metabolic process • positive regulation of choline O-acetyltransferase activity • lipid transport • protein targeting to lysosome • negative regulation of neurofibrillary tangle assembly • endocytosis • positive regulation of protein catabolic process • lipid metabolic process • negative regulation of amyloid-beta formation • negative regulation of protein oligomerization • negative regulation of neurogenesis • protein maturation • negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process • cholesterol metabolic process • negative regulation of protein binding • positive regulation of ER to Golgi vesicle-mediated transport • receptor-mediated endocytosis • positive regulation of early endosome to recycling endosome transport • post-Golgi vesicle-mediated transport • protein targeting to Golgi • negative regulation of MAP kinase activity • positive regulation of endocytic recycling • regulation of smooth muscle cell migration • positive regulation of protein localization to early endosome • transport • negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process • positive regulation of protein exit from endoplasmic reticulum • protein retention in Golgi apparatus • negative regulation of neuron death • signal transduction • cellular protein metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6653	20660
Ensembl	ENSG00000137642	ENSMUSG00000049313
UniProt	Q92673	O88307
RefSeq (mRNA)	NM_003105	NM_011436
RefSeq (protein)	NP_003096	NP_035566
Location (UCSC)	Chr 11: 121.45 – 121.63 Mb	Chr 11: 41.96 – 42.12 Mb
PubMed search

2DM4, 3G2S, 3G2T, 3WSX, 3WSY, 3WSZ

6653

20660

ENSG00000137642

ENSMUSG00000049313

Q92673

O88307

NM_003105

NM_011436

NP_003096

NP_035566

Sortilin-related receptor, L(DLR class) A repeats containing is a protein that in humans is encoded by the SORL1 gene.

SORL1 (also known as SORLA, SORLA1, or LR11) is a neuronal apolipoprotein E receptor, the gene for which is predominantly expressed in the central nervous system.

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Wikipedia