SPINT2

SPINT2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4U32
Identifiers
Aliases	SPINT2, DIAR3, HAI-2, HAI2, Kop, PB, serine peptidase inhibitor, Kunitz type, 2, serine peptidase inhibitor, Kunitz type 2
External IDs	MGI: 1338031 HomoloGene: 7955 GeneCards: SPINT2
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.2 Start 38,244,035 bp End 38,292,614 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 B1 Start 29,256,323 bp End 29,281,912 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • peptidase inhibitor activity • endopeptidase inhibitor activity • serine-type endopeptidase inhibitor activity Cellular component • cytoplasm • integral component of membrane • extracellular region • membrane • plasma membrane Biological process • negative regulation of cell motility • negative regulation of peptidase activity • negative regulation of cell-cell adhesion • establishment or maintenance of cell polarity • negative regulation of neural precursor cell proliferation • neural tube closure • negative regulation of endopeptidase activity • epithelial cell morphogenesis involved in placental branching • cellular response to BMP stimulus • basement membrane organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10653	20733
Ensembl	ENSG00000167642	ENSMUSG00000074227
UniProt	O43291	Q9WU03
RefSeq (mRNA)	NM_021102 NM_001166103	NM_001082548 NM_011464
RefSeq (protein)	NP_001159575 NP_066925	NP_001076017 NP_035594
Location (UCSC)	Chr 19: 38.24 – 38.29 Mb	Chr 7: 29.26 – 29.28 Mb
PubMed search

4U32

10653

20733

ENSG00000167642

ENSMUSG00000074227

O43291

Q9WU03

NM_021102
NM_001166103

NM_001082548
NM_011464

NP_001159575
NP_066925

NP_001076017
NP_035594

Kunitz-type protease inhibitor 2 is an enzyme inhibitor that in humans is encoded by the SPINT2 gene. SPINT2 is a transmembrane protein with two extracellular Kunitz domains to inhibit serine proteases. This gene is a presumed tumor suppressor by inhibiting HGF activator which prevents the formation of active . Mutations in SPINT2 could result in congenital sodium diarrhea (CSD).

...
Wikipedia