SUPT5H

SUPT5H
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DO3, 2E6Z, 2E70, 3H7H, 4L1U
Identifiers
Aliases	SUPT5H, SPT5, SPT5H, Tat-CT1, SPT5 homolog, DSIF elongation factor subunit
External IDs	MGI: 1202400 HomoloGene: 2384 GeneCards: SUPT5H
Gene ontology Molecular function • protein binding • protein heterodimerization activity • enzyme binding • chromatin binding • RNA binding Cellular component • nucleoplasm • DSIF complex • nucleus Biological process • chromatin remodeling • negative regulation of mRNA polyadenylation • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • transcription elongation from RNA polymerase II promoter • regulation of DNA-templated transcription, elongation • negative regulation of transcription from RNA polymerase II promoter • 7-methylguanosine mRNA capping • transcription from RNA polymerase II promoter • response to organic substance • transcription, DNA-templated • negative regulation of DNA-templated transcription, elongation • positive regulation of DNA-templated transcription, elongation • positive regulation of macroautophagy • DNA-templated transcription, elongation • single stranded viral RNA replication via double stranded DNA intermediate • positive regulation of viral transcription • cell cycle • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6829	20924
Ensembl	ENSG00000196235	ENSMUSG00000003435
UniProt	O00267	O55201
RefSeq (mRNA)	NM_001111020 NM_001130824 NM_001130825 NM_003169 NM_001319990 NM_001319991	NM_013676
RefSeq (protein)	NP_001104490 NP_001124296 NP_001124297 NP_001306919 NP_001306920 NP_003160	NP_038704.1 NP_038704
Location (UCSC)	Chr 19: 39.44 – 39.48 Mb	Chr 7: 28.31 – 28.34 Mb
PubMed search

2DO3, 2E6Z, 2E70, 3H7H, 4L1U

6829

20924

ENSG00000196235

ENSMUSG00000003435

O00267

O55201

NM_001319991

NM_013676

NP_003160

NP_038704.1
NP_038704

Transcription elongation factor SPT5 is a protein that in humans is encoded by the SUPT5H gene.

SUPT5H has been shown to interact with:

Model organisms have been used in the study of SUPT5H function. A conditional knockout mouse line called Supt5^{tm2a(KOMP)Wtsi} was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping

...
Wikipedia