SYN1

SYN1
Identifiers
Aliases	SYN1, SYN1a, SYN1b, SYNI, Synapsin I
External IDs	MGI: 98460 HomoloGene: 48483 GeneCards: SYN1
Gene ontology Molecular function • transporter activity • calcium-dependent protein binding • catalytic activity • protein binding • actin binding • ATP binding • protein kinase binding Cellular component • cytosol • Golgi apparatus • postsynaptic density • synaptic vesicle • myelin sheath • synapse • synaptic vesicle membrane • presynaptic active zone • axon • cell junction • terminal bouton • dendrite • intracellular organelle • synaptonemal complex • anchored component of synaptic vesicle membrane Biological process • regulation of neurotransmitter secretion • regulation of synaptic vesicle exocytosis • neurotransmitter secretion • chemical synaptic transmission • synaptic vesicle clustering Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6853	20964
Ensembl	ENSG00000008056	ENSMUSG00000037217
UniProt	P17600	O88935
RefSeq (mRNA)	NM_133499 NM_006950	NM_001110780 NM_013680
RefSeq (protein)	NP_008881 NP_598006	NP_001104250.1 NP_038708.3 NP_001104250 NP_038708
Location (UCSC)	Chr X: 47.57 – 47.62 Mb	Chr X: 20.86 – 20.92 Mb
PubMed search

6853

20964

ENSG00000008056

ENSMUSG00000037217

P17600

O88935

NM_133499
NM_006950

NM_001110780
NM_013680

NP_008881
NP_598006

NP_001104250.1
NP_038708.3
NP_001104250
NP_038708

Synapsin I, is the collective name for Synapsin Ia and Synapsin Ib, two nearly identical phosphoproteins that in humans are encoded by the SYN1 gene. In its phosphorylated form, Synapsin I may also be referred to as phosphosynaspin I. Synapsin I is the first of the proteins in the synapsin family of phosphoproteins in the synaptic vesicles present in the central and peripheral nervous systems. Synapsin Ia and Ib are close in length and almost the same in make up, however, Synapsin Ib stops short of the last segment of the C-terminal in the amino acid sequence found in Synapsin Ia.

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