Sec61
| Identifiers | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Symbol | SecY | ||||||||
| Pfam | PF00344 | ||||||||
| TCDB | 3.A.5 | ||||||||
| OPM superfamily | 19 | ||||||||
| OPM protein | 2wwb | ||||||||
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| Available protein structures: | |
|---|---|
| Pfam | structures |
| PDB | RCSB PDB; PDBe; PDBj |
| PDBsum | structure summary |
Sec61 is an endoplasmic reticulum (ER) membrane protein translocator (aka translocon). It is a doughnut shaped pore through the membrane with 3 major subunits (heterotrimeric). It has a region called the plug that blocks transport into or out of the ER. This plug is displaced when the hydrophobic region of a nascent polypeptide interacts with another region of Sec61 called the seam, allowing translocation of the polypeptide into the ER lumen.
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