"Second Round K.O." was a single from Canibus' debut album, Can-I-Bus. The song was produced by Wyclef Jean and his cousin Jerry Wonder and featured spoken vocals from boxer Mike Tyson.

The song became Canibus's only top 40 single, peaking at number 28 on the Billboard Hot 100.

"Second Round K.O." was a diss track by Canibus directed at LL Cool J. The feud had started after Canibus' appearance on LL's "4, 3, 2, 1. Canibus' original verse contained the lyrics "L, is that a mic on your arm? Let me borrow that", which LL took offense to. LL responded by writing an indirect diss towards Canibus on the same song. Prior to the songs release, LL approached Canibus and told him that if he wanted to remain on the song, he would have to change his lines, to which Canibus agreed, however, LL kept his original verse. When Canibus' original verse leaked, a feud started between the two rappers. LL suggested the two make a song together to squash the beef after he was done filming Any Given Sunday, Canibus, however, recorded and released "Second Round K.O." instead. LL would respond with "The Ripper Strikes Back" and "Back Where I Belong" and even thanked Canibus in the liner notes of his album G.O.A.T. for "inspiration". In the song, Canibus says "the greatest rapper of all time died on March 9." This is a reference to The Notorious B.I.G., who was a legendary rap artist who was brutally murdered on March 9, 1997. Canibus followed up his diss 1 year later, with a record entitled "Rip The Jacker", over a polished remake of the beat from LL Cool J's "I'm Bad".

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