Shepperdine is a rural land forming the north of Oldbury-on-Severn in South Gloucestershire, England, with a border with Stroud (district). It comprises farms and a scarcely populated hamlet. The land lies wholly on the flood plain of the River Severn.
Shepperdine has a Church of England chapel of ease (small church) dedicated to St Mary next to Manor Farm in Nupdown Road. It was rebuilt after a fire in 1897, and contains several Grade II listed tombs. The ecclesiastical parish is Oldbury on Severn, whose cleric is the vicar of Thornbury and that small town was its medieval (ancient) parish; it is centred 3 miles (4.8 km) south-east.
Shepperdine House features an early C19 facade, and has "three bays, with cornice and parapet, and square-columned porch".
In a field to the northeast of the hamlet items of Roman and early medieval pottery have been unearthed.
In the summer 2009 the German power company E.ON started to acquire land from local farmers with the intention of constructing of a 3,300 megawatt nuclear power station on the banks of the River Severn. They formed a joint venture with German power company RWE. The two companies bought the existing Oldbury and Wylfa Magnox Nuclear Power Stations from the NDA for the sum of £500 million. RWE and Eon have now formed a company called Horizon to proceed with the development. In March 2012 it was announced that they had decided to not go ahead with the construction, but in 2014 Horizon bought an old inn in Shepperdine to make way for the new power station.