Silandrone

Silandrone

Clinical data
Routes of administration	Oral, intramuscular injection, subcutaneous injection
Identifiers
IUPAC name (8R,9S,10R,13S,14S,17S)-10,13-dimethyl-17-trimethylsilyloxy-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
Synonyms	Testosterone 17β-trimethylsilyl ether; Testosterone O-trimethylsilyl ether; 17β-Trimethylsilyltestosterone; O-Trimethylsilyltestosterone; 17β-(trimethylsiloxy)androst-4-en-3-one; SC-16148; NSC-95147
CAS Number	5055-42-5
PubChem (CID)	68627
ChemSpider	61886 Y
UNII	YY7GL3CCE9 Y
KEGG	D05837
ChEBI	CHEBI:607921
ChEMBL	CHEMBL485687
ECHA InfoCard	100.023.414
Chemical and physical data
Formula	C22H36O2Si
Molar mass	360.613 g/mol
3D model (Jmol)	Interactive image
SMILES C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O[Si](C)(C)C)CCC4=CC(=O)CC[C@]34C
InChI InChI=1S/C22H36O2Si/c1-21-12-10-16(23)14-15(21)6-7-17-18-8-9-20(24-25(3,4)5)22(18,2)13-11-19(17)21/h14,17-20H,6-13H2,1-5H3/t17-,18-,19-,20-,21-,22-/m0/s1 Key:HNZDTAXZHUDITM-WLNPFYQQSA-N

Silandrone (INN, USAN) (developmental code names SC-16148, NSC-95147), also known as testosterone 17β-trimethylsilyl ether or 17β-trimethylsilyltestosterone, as well as 17β-(trimethylsiloxy)androst-4-en-3-one, is a synthetic anabolic-androgenic steroid (AAS) and an androgen ether – specifically, the 17β-trimethylsilyl ether of testosterone – which was developed by the G. D. Searle & Company in the 1960s but was never marketed. It has a very long duration of action when given via subcutaneous or intramuscular injection as well as, notably, significantly greater potency than that of testosterone propionate. In addition, it is notable that silandrone, unlike testosterone and most esters of testosterone like testosterone propionate, is orally active.