Sortilin 1

SORT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3F6K, 3G2U, 3G2V, 4MSL, 4N7E, 4PO7
Identifiers
Aliases	SORT1, Gp95, LDLCQ6, NT3, NTR3, Sortilin 1
External IDs	MGI: 1338015 HomoloGene: 136097 GeneCards: SORT1
Gene location (Human) Chr. Chromosome 1 (human) Band No data available Start 109,309,568 bp End 109,397,951 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band No data available Start 108,284,082 bp End 108,361,511 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • nerve growth factor receptor activity • neurotensin receptor activity, non-G-protein coupled • nerve growth factor binding • protein binding • enzyme binding Cellular component • integral component of membrane • endosome • Golgi apparatus • nuclear membrane • endoplasmic reticulum membrane • membrane • intracellular membrane-bounded organelle • plasma membrane • Golgi cisterna membrane • cell surface • lysosomal membrane • neuronal cell body • dendrite • early endosome • endoplasmic reticulum • perinuclear region of cytoplasm • clathrin-coated pit • trans-Golgi network transport vesicle • lysosome • endosome membrane • clathrin-coated vesicle • nucleus • cytosol • cytoplasmic vesicle membrane • cytoplasmic vesicle Biological process • G-protein coupled receptor signaling pathway • cell differentiation • myotube differentiation • negative regulation of fat cell differentiation • endocytosis • neurotrophin TRK receptor signaling pathway • ossification • endosome transport via multivesicular body sorting pathway • vesicle organization • endosome to lysosome transport • Golgi to endosome transport • positive regulation of epithelial cell apoptotic process • multicellular organism development • response to insulin • plasma membrane to endosome transport • regulation of gene expression • negative regulation of lipoprotein lipase activity • glucose import • neuropeptide signaling pathway • extrinsic apoptotic signaling pathway via death domain receptors • nerve growth factor signaling pathway • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6272	20661
Ensembl	ENSG00000134243	ENSMUSG00000068747
UniProt	Q99523	Q6PHU5
RefSeq (mRNA)	NM_001205228 NM_002959	NM_001271599 NM_019972
RefSeq (protein)	NP_001192157 NP_002950	NP_001258528 NP_064356
Location (UCSC)	Chr 1: 109.31 – 109.4 Mb	Chr 1: 108.28 – 108.36 Mb
PubMed search

3F6K, 3G2U, 3G2V, 4MSL, 4N7E, 4PO7

6272

20661

ENSG00000134243

ENSMUSG00000068747

Q99523

Q6PHU5

NM_001205228
NM_002959

NM_001271599
NM_019972

NP_001192157
NP_002950

NP_001258528
NP_064356

Sortilin (SORT1) is a protein that in humans is encoded by the SORT1 gene on chromosome 1. This protein is a type I membrane glycoprotein in the vacuolar protein sorting 10 protein (Vps10p) family of sorting receptors. While it is ubiquitously expressed in many tissues, sortilin is most abundant in the central nervous system. At the cellular level, sortilin functions in protein transport between the Golgi apparatus, endosome, lysosome, and plasma membrane, leading to its involvement in multiple biological processes such as glucose and lipid metabolism as well as neural development and cell death. Moreover, the function and role of sortilin is now emerging in several major human diseases such as atherosclerosis and coronary artery disease, Alzheimer’s disease, and cancer. The SORT1 gene also contains one of 27 loci associated with increased risk of coronary artery disease.

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Wikipedia