Sulpiride

Sulpiride
Clinical data


Trade names	Eglonyl, Dolmatil, Sulpor
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral (tablets, capsules, oral solution), IM
ATC code	N05AL01 (WHO)
Legal status
Legal status	UK: POM (Prescription only) In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability	25–40%
Protein binding	<40%
Metabolism	Not metabolised
Biological half-life	6-8 hours
Excretion	Renal (70–90%),Fecal (~95% as the unchanged drug)
Identifiers
IUPAC name N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide
CAS Number	15676-16-1^Y
PubChem CID	5355
IUPHAR/BPS	5501
DrugBank	DB00391^Y
ChemSpider	5162^Y
UNII	7MNE9M8287
KEGG	D01226^Y
ChEMBL	CHEMBL26^Y
ECHA InfoCard	100.036.124
Chemical and physical data
Formula	C₁₅H₂₃N₃O₄S
Molar mass	341.427 g/mol
3D model (Jmol)	Interactive image
SMILES O=S(=O)(N)c1cc(c(OC)cc1)C(=O)NCC2N(CC)CCC2
InChI InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)^Y Key:BGRJTUBHPOOWDU-UHFFFAOYSA-N^Y

Sulpiride (brand names Dogmatil ( DE, HK, SG, PH), Dolmatil (IE, UK), Eglonyl (RU, ZA), Espiride (ZA), Modal (IL), Prometar (UY), Sulpor (UK) and others) is an atypical antipsychotic drug (although some texts have referred to it as a typical antipsychotic) of the benzamide class used mainly in the treatment of psychosis associated with schizophrenia and major depressive disorder, and sometimes used in low dosage to treat anxiety and mild depression. Sulpiride is commonly used in Europe, Russia and Japan. Levosulpiride is its purified levo-isomer and is sold in India for similar purpose. So far it has not been approved in the United States, Canada and Australia. The drug is chemically and clinically similar to amisulpride.