T-bet

TBX21
Identifiers
Aliases	TBX21, T-PET, T-bet, TBET, TBLYM, T-box 21
External IDs	MGI: 1888984 HomoloGene: 8353 GeneCards: TBX21
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • transcription regulatory region DNA binding • DNA binding Cellular component • neuronal cell body • nucleus Biological process • multicellular organism development • positive regulation of transcription, DNA-templated • cellular response to organic substance • positive regulation of isotype switching to IgG isotypes • response to virus • T cell differentiation • regulation of transcription, DNA-templated • lymphocyte migration • transcription, DNA-templated • regulation of immune response Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	30009	57765
Ensembl	ENSG00000073861	ENSMUSG00000001444
UniProt	Q9UL17	Q9JKD8
RefSeq (mRNA)	NM_013351	NM_019507
RefSeq (protein)	NP_037483	NP_062380.2 NP_062380
Location (UCSC)	Chr 17: 47.73 – 47.75 Mb	Chr 11: 97.1 – 97.12 Mb
PubMed search

30009

57765

ENSG00000073861

ENSMUSG00000001444

Q9UL17

Q9JKD8

NM_013351

NM_019507

NP_037483

NP_062380.2
NP_062380

T-box transcription factor TBX21 is a protein that in humans is encoded by the TBX21 gene.

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells.

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