TEK tyrosine kinase

TEK

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4K0V, 1FVR, 2GY5, 2GY7, 2OO8, 2OSC, 2P4I, 2WQB, 3L8P, 4X3J

Identifiers

Aliases

TEK, CD202B, TIE-2, TIE2, VMCM, VMCM1, TEK tyrosine kinase, TEK receptor tyrosine kinase, GLC3E

External IDs

MGI: 98664 HomoloGene: 397 GeneCards: TEK

Gene ontology
Molecular function	• transferase activity • protein kinase activity • nucleotide binding • growth factor binding • kinase activity • protein binding • transmembrane receptor protein tyrosine kinase activity • protein tyrosine kinase activity • ATP binding • receptor activity • Ras guanyl-nucleotide exchange factor activity
Cellular component	• cytoplasm • integral component of membrane • membrane • cell-cell junction • focal adhesion • integral component of plasma membrane • stress fiber • extracellular region • microvillus • cell surface • basal plasma membrane • cell junction • basolateral plasma membrane • apical plasma membrane • actin filament • membrane raft • cytoskeleton • microtubule organizing center • plasma membrane
Biological process	• negative regulation of endothelial cell apoptotic process • positive regulation of protein kinase B signaling • positive regulation of protein phosphorylation • intracellular signal transduction • response to hypoxia • positive regulation of endothelial cell proliferation • heart trabecula formation • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • regulation of endothelial cell apoptotic process • cell-cell signaling • response to peptide hormone • sprouting angiogenesis • negative regulation of apoptotic process • endochondral ossification • positive regulation of intracellular signal transduction • response to organic substance • positive regulation of angiogenesis • MAPK cascade • positive regulation of phosphatidylinositol 3-kinase activity • positive regulation of endothelial cell migration • response to estrogen • heart development • regulation of vascular permeability • protein phosphorylation • protein oligomerization • endothelial cell proliferation • angiogenesis • Tie signaling pathway • positive regulation of ERK1 and ERK2 cascade • negative regulation of angiogenesis • protein autophosphorylation • positive regulation of focal adhesion assembly • regulation of establishment or maintenance of cell polarity • positive regulation of phosphatidylinositol 3-kinase signaling • peptidyl-tyrosine phosphorylation • substrate adhesion-dependent cell spreading • response to cAMP • definitive hemopoiesis • positive regulation of actin cytoskeleton reorganization • negative regulation of inflammatory response • leukocyte migration • signal transduction • positive regulation of GTPase activity • glomerulus vasculature development
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


7010


21687

Ensembl


ENSG00000120156


ENSMUSG00000006386

UniProt


Q02763


Q02858

RefSeq (mRNA)


NM_000459 NM_001290077 NM_001290078


NM_001290549 NM_001290551 NM_013690

RefSeq (protein)


NP_000450 NP_001277006 NP_001277007


NP_001277478 NP_001277480 NP_038718

Location (UCSC)

Chr 9: 27.11 – 27.23 Mb

Chr 4: 94.74 – 94.87 Mb

PubMed search

4K0V, 1FVR, 2GY5, 2GY7, 2OO8, 2OSC, 2P4I, 2WQB, 3L8P, 4X3J

NM_000459
NM_001290077
NM_001290078

NM_001290549
NM_001290551
NM_013690

NP_000450
NP_001277006
NP_001277007

...
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