TFAP2A

TFAP2A

Identifiers

TFAP2A, AP-2, AP-2alpha, AP2TF, BOFS, TFAP2, transcription factor AP-2 alpha

External IDs

MGI: 104671 HomoloGene: 2421 GeneCards: TFAP2A

Genetically Related Diseases

amyotrophic lateral sclerosis

Gene ontology
Molecular function	• DNA binding • protein dimerization activity • protein homodimerization activity • transcription factor activity, sequence-specific DNA binding • transcription coactivator activity • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • chromatin binding • core promoter proximal region sequence-specific DNA binding • transcription regulatory region sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • transcription regulatory region DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • RNA polymerase II core promoter sequence-specific DNA binding • sequence-specific DNA binding
Cellular component	• centrosome • Golgi apparatus • intracellular membrane-bounded organelle • nucleus • nucleoplasm • cytosol
Biological process	• palate development • cellular response to iron ion • regulation of transcription, DNA-templated • retina layer formation • kidney development • positive regulation of bone mineralization • trigeminal nerve development • negative regulation of transcription by competitive promoter binding • optic vesicle morphogenesis • bone morphogenesis • negative regulation of apoptotic process • sensory perception of sound • eyelid development in camera-type eye • transcription, DNA-templated • positive regulation of transcription, DNA-templated • positive regulation of neuron apoptotic process • positive regulation of gene expression • inner ear morphogenesis • optic cup structural organization • regulation of cell differentiation • embryonic cranial skeleton morphogenesis • negative regulation of reactive oxygen species metabolic process • negative regulation of transcription, DNA-templated • embryonic forelimb morphogenesis • oculomotor nerve formation • negative regulation of cell proliferation • positive regulation of tooth mineralization • transcription from RNA polymerase II promoter • negative regulation of transcription from RNA polymerase II promoter • regulation of transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE TFAP2A 204653 at tn.png

PBB GE TFAP2A 204654 s at tn.png

PBB GE TFAP2A 210669 at tn.png

More reference expression data

Orthologs

Species

Human

Mouse


7020


21418


ENSG00000137203


ENSMUSG00000021359


P05549 Q96SH1


P34056

RefSeq (mRNA)


NM_001032280 NM_001042425 NM_003220


NM_001122948 NM_001301674 NM_011547

RefSeq (protein)


NP_001027451 NP_001035890 NP_003211


NP_001288603.1 NP_035677.2 NP_001116420 NP_001288603 NP_035677

Location (UCSC)

Chr 6: 10.39 – 10.42 Mb

Chr 13: 40.72 – 40.73 Mb

PubMed search

ENSG00000137203

ENSMUSG00000021359

NM_001032280
NM_001042425
NM_003220

NM_001122948
NM_001301674
NM_011547

NP_001027451
NP_001035890
NP_003211

NP_001288603.1
NP_035677.2
NP_001116420
NP_001288603
NP_035677

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Wikipedia

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