TGF beta receptor 2

TGFBR2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1KTZ, 1M9Z, 1PLO, 2PJY, 3KFD, 4P7U, 4XJJ, 5E92, 5E91, 5E8V, 5E8Y

Identifiers

Aliases

TGFBR2, AAT3, FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, TAAD2, TGFR-2, TGFbeta-RII, transforming growth factor beta receptor 2

External IDs

OMIM: 190182 MGI: 98729 HomoloGene: 2435 GeneCards: TGFBR2

Genetically Related Diseases

breast cancer

Gene ontology
Molecular function	• transforming growth factor beta-activated receptor activity • kinase activity • ATP binding • type III transforming growth factor beta receptor binding • protein kinase activity • signal transducer, downstream of receptor, with serine/threonine kinase activity • transforming growth factor beta receptor activity, type II • metal ion binding • protein serine/threonine kinase activity • transferase activity • type I transforming growth factor beta receptor binding • mitogen-activated protein kinase kinase kinase binding • transmembrane receptor protein serine/threonine kinase activity • protein binding • SMAD binding • receptor activity • nucleotide binding • glycosaminoglycan binding • transforming growth factor beta binding
Cellular component	• cytoplasm • cytosol • membrane • caveola • cell surface • membrane raft • integral component of membrane • receptor complex • plasma membrane • transforming growth factor beta receptor complex • integral component of plasma membrane • external side of plasma membrane
Biological process	• growth plate cartilage development • response to cholesterol • lens fiber cell apoptotic process • response to steroid hormone • positive regulation of T cell tolerance induction • receptor-mediated endocytosis • response to organic substance • vasculogenesis • protein phosphorylation • positive regulation of B cell tolerance induction • positive regulation of reactive oxygen species metabolic process • blood vessel development • positive regulation of mesenchymal cell proliferation • animal organ regeneration • animal organ morphogenesis • transforming growth factor beta receptor signaling pathway • embryo implantation • negative regulation of cell proliferation • apoptotic process • pathway-restricted SMAD protein phosphorylation • common-partner SMAD protein phosphorylation • signal transduction by protein phosphorylation • bronchus morphogenesis • lung development • response to mechanical stimulus • positive regulation of epithelial cell migration • in utero embryonic development • negative regulation of transforming growth factor beta receptor signaling pathway • heart development • cartilage development • positive regulation of tolerance induction to self antigen • branching involved in blood vessel morphogenesis • positive regulation of skeletal muscle tissue regeneration • smoothened signaling pathway • negative regulation of cardiac muscle cell proliferation • Notch signaling pathway • palate development • cell differentiation • phosphorylation • response to nutrient • mammary gland morphogenesis • wound healing • response to glucose • positive regulation of epithelial to mesenchymal transition • positive regulation of angiogenesis • response to estrogen • gastrulation • regulation of gene expression • embryonic cranial skeleton morphogenesis • peptidyl-threonine phosphorylation • trachea formation • lung lobe morphogenesis • positive regulation of smooth muscle cell proliferation • lung morphogenesis • response to organic cyclic compound • trachea morphogenesis • aging • myeloid dendritic cell differentiation • bronchus development • brain development • transmembrane receptor protein serine/threonine kinase signaling pathway • lens development in camera-type eye • regulation of cell proliferation • peptidyl-serine phosphorylation • positive regulation of cell proliferation • embryonic hemopoiesis • growth plate cartilage chondrocyte growth • regulation of growth • positive regulation of NK T cell differentiation • digestive tract development • activation of protein kinase activity • response to drug • response to hypoxia • heart looping • outflow tract septum morphogenesis • membranous septum morphogenesis • outflow tract morphogenesis • atrioventricular valve morphogenesis • tricuspid valve morphogenesis • cardiac left ventricle morphogenesis • endocardial cushion fusion • ventricular septum morphogenesis • positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation • cell proliferation involved in endocardial cushion morphogenesis • positive regulation of CD4-positive, alpha-beta T cell proliferation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


7048


21813

Ensembl


ENSG00000163513


ENSMUSG00000032440

UniProt


P37173


Q62312

RefSeq (mRNA)


NM_001024847 NM_003242


NM_009371 NM_029575

RefSeq (protein)


NP_001020018 NP_003233


NP_033397.3 NP_033397 NP_083851

Location (UCSC)

Chr 3: 30.61 – 30.69 Mb

Chr 9: 116.08 – 116.18 Mb

PubMed search

Transforming growth factor beta receptor 2 ectodomain

crystal structure of human tgf-beta type ii receptor ligand binding domain

Identifiers

Symbol

ecTbetaR2

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

1KTZ, 1M9Z, 1PLO, 2PJY, 3KFD, 4P7U, 4XJJ, 5E92, 5E91, 5E8V, 5E8Y

NM_001024847
NM_003242

NM_009371
NM_029575

NP_001020018
NP_003233

...
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