TNFRSF6

FAS

Protein FAS PDB 1ddf.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1DDF, 3EWT, 3EZQ, 3THM, 3TJE, 2NA7

Identifiers

FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6, Fas cell surface death receptor

External IDs

MGI: 95484 HomoloGene: 27 GeneCards: FAS

Gene location (Human)

Chr.	Chromosome 10 (human)

Band	10q23.31	Start	88,990,582 bp
Band	10q23.31	End	89,015,785 bp

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)

Band	19 C1\|19 29.48 cM	Start	34,290,659 bp
Band	19 C1\|19 29.48 cM	End	34,327,770 bp

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• kinase binding • protein binding • transmembrane signaling receptor activity • receptor activity • signal transducer activity • identical protein binding • tumor necrosis factor-activated receptor activity • tumor necrosis factor binding • calmodulin binding
Cellular component	• CD95 death-inducing signaling complex • membrane • extracellular region • cell surface • extracellular exosome • integral component of membrane • plasma membrane • integral component of plasma membrane • external side of plasma membrane • death-inducing signaling complex • membrane raft • cytosol • nuclear body • mitochondrion
Biological process	• renal system process • activation-induced cell death of T cells • tumor necrosis factor-mediated signaling pathway • T cell homeostasis • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand • cellular response to mechanical stimulus • circadian rhythm • apoptotic signaling pathway • positive regulation of extrinsic apoptotic signaling pathway • regulation of extrinsic apoptotic signaling pathway via death domain receptors • activation of cysteine-type endopeptidase activity involved in apoptotic process • apoptotic process • activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway • spleen development • negative thymic T cell selection • regulation of lymphocyte differentiation • necroptotic signaling pathway • motor neuron apoptotic process • inflammatory response • regulation of myeloid cell differentiation • protein homooligomerization • response to toxic substance • B cell mediated immunity • neuron apoptotic process • positive regulation of protein homooligomerization • cellular response to lithium ion • positive regulation of lymphocyte apoptotic process • negative regulation of apoptotic process • immune response • gene expression • protein complex assembly • cellular response to hyperoxia • negative regulation of B cell activation • response to glucocorticoid • extrinsic apoptotic signaling pathway in absence of ligand • inflammatory cell apoptotic process • immunoglobulin production • signal transduction • hepatocyte apoptotic process • response to lipopolysaccharide • extrinsic apoptotic signaling pathway • regulation of apoptotic process • positive regulation of apoptotic process • regulation of cell proliferation • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • multicellular organism development • extrinsic apoptotic signaling pathway via death domain receptors • positive regulation of protein phosphorylation • regulation of stress-activated MAPK cascade • cellular response to amino acid starvation • Fas signaling pathway • positive regulation of apoptotic signaling pathway • positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


355


14102


ENSG00000026103


ENSMUSG00000024778


P25445


P25446

RefSeq (mRNA)

NM_000043 NM_152871 NM_152872 NM_152873 NM_152874
NM_152875 NM_152876 NM_152877 NM_001320619


NM_001146708 NM_007987

RefSeq (protein)


NP_000034 NP_001307548 NP_690610 NP_690611


NP_001140180 NP_032013

Location (UCSC)

Chr 10: 88.99 – 89.02 Mb

Chr 10: 34.29 – 34.33 Mb

PubMed search

1DDF, 3EWT, 3EZQ, 3THM, 3TJE, 2NA7

ENSG00000026103

ENSMUSG00000024778

NM_152875
NM_152876
NM_152877
NM_001320619

NM_001146708
NM_007987

NP_000034
NP_001307548
NP_690610
NP_690611

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Wikipedia

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