TPCN1

TPCN1
Identifiers
Aliases	TPCN1, TPC1, two pore segment channel 1
External IDs	MGI: 2182472 HomoloGene: 9905 GeneCards: TPCN1
Targeted by Drug
phosphatidyl (3,5) inositol biphosphate, verapamil
Gene ontology Molecular function • calcium channel activity • voltage-gated ion channel activity • ion channel activity • protein binding • identical protein binding • NAADP-sensitive calcium-release channel activity • voltage-gated calcium channel activity Cellular component • integral component of membrane • endosome • membrane • plasma membrane • lysosomal membrane • lysosome • endosome membrane Biological process • membrane depolarization during action potential • positive regulation of autophagy • regulation of ion transmembrane transport • ion transport • ion transmembrane transport • calcium ion transmembrane transport • transport • calcium ion transport • transmembrane transport • release of sequestered calcium ion into cytosol Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	53373	252972
Ensembl	ENSG00000186815	ENSMUSG00000032741
UniProt	Q9ULQ1	Q9EQJ0
RefSeq (mRNA)	NM_001143819 NM_001301214 NM_017901	NM_145853
RefSeq (protein)	NP_001137291 NP_001288143 NP_060371	NP_665852.1 NP_665852
Location (UCSC)	Chr 12: 113.22 – 113.3 Mb	Chr 5: 120.53 – 120.59 Mb
PubMed search

53373

252972

ENSG00000186815

ENSMUSG00000032741

Q9ULQ1

Q9EQJ0

NM_001143819
NM_001301214
NM_017901

NM_145853

NP_001137291
NP_001288143
NP_060371

NP_665852.1
NP_665852

Two pore segment channel 1 (TPC1) is a human protein encoded by the TPCN1 gene. The protein encoded by this gene is an ion channel. In contrast to other calcium and sodium channels which have four homologous domains, each containing 6 transmembrane segments (S1 to S6), TPCN1 only contains two domains (each containing segments S1 to S6).

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