TRAF5

TRAF5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4GJH
Identifiers
Aliases	TRAF5, MGC:39780, RNF84, TNF receptor associated factor 5
External IDs	MGI: 107548 HomoloGene: 27079 GeneCards: TRAF5
Gene ontology Molecular function • thioesterase binding • zinc ion binding • protein binding • ubiquitin protein ligase binding • metal ion binding • identical protein binding Cellular component • cytosol • cytoplasmic side of plasma membrane • centrosome • CD40 receptor complex • cytoplasm Biological process • regulation of apoptotic process • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of sequence-specific DNA binding transcription factor activity • positive regulation of NF-kappaB transcription factor activity • signal transduction • apoptotic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7188	22033
Ensembl	ENSG00000082512	n/a
UniProt	O00463	P70191
RefSeq (mRNA)	NM_001033910 NM_004619 NM_145759 NM_001319207	NM_011633
RefSeq (protein)	NP_001029082 NP_001306136 NP_004610 NP_665702	NP_035763
Location (UCSC)	Chr 1: 211.33 – 211.37 Mb	n/a
PubMed search

4GJH

7188

22033

ENSG00000082512

n/a

O00463

P70191

NM_001033910
NM_004619
NM_145759
NM_001319207

NM_011633

NP_001029082
NP_001306136
NP_004610
NP_665702

NP_035763

TNF receptor-associated factor 5 is a protein that in humans is encoded by the TRAF5 gene.

The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Alternate transcriptional splice variants have been characterized.

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Wikipedia