TRPV5

TRPV5
Identifiers
Aliases	TRPV5, CAT2, ECAC1, OTRPC3, transient receptor potential cation channel subfamily V member 5
External IDs	MGI: 2429764 HomoloGene: 10520 GeneCards: TRPV5
Gene ontology Molecular function • ion channel activity • protein binding • calmodulin binding • metal ion binding • calcium channel activity Cellular component • integral component of membrane • plasma membrane • integral component of plasma membrane • apical plasma membrane • membrane Biological process • ion transport • protein tetramerization • calcium ion transport • transmembrane transport • regulation of urine volume • calcium ion homeostasis • calcium ion transmembrane transport • calcium ion import across plasma membrane • transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	56302	194352
Ensembl	ENSG00000274348 ENSG00000127412	ENSMUSG00000036899
UniProt	Q9NQA5	P69744
RefSeq (mRNA)	NM_019841	NM_001007572
RefSeq (protein)	NP_062815	NP_001007573
Location (UCSC)	Chr 7: 142.91 – 142.93 Mb	Chr 6: 41.65 – 41.68 Mb
PubMed search

56302

194352

ENSG00000274348
ENSG00000127412

ENSMUSG00000036899

Q9NQA5

P69744

NM_019841

NM_001007572

NP_062815

NP_001007573

Transient receptor potential cation channel subfamily V member 5 is a protein that in humans is encoded by the TRPV5 gene.

TRPV5 is mainly expressed in kidney epithelial cells, where it plays an important role in the reabsorption of Ca²⁺. Genetic deletion of TRPV5 in mice leads to Ca²⁺ loss in the urine, and consequentual hyperparathyroidism, and bone loss.

This gene is a member of the transient receptor family and the TRPV subfamily. The calcium-selective channel , TRPV5, encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level.

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Wikipedia