TXK (gene)

TXK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DM0
Identifiers
Aliases	TXK, BTKL, PSCTK5, PTK4, RLK, TKL, TXK tyrosine kinase
External IDs	MGI: 102960 HomoloGene: 2497 GeneCards: TXK
Targeted by Drug
bosutinib
Gene ontology Molecular function • transferase activity • nucleotide binding • DNA binding • protein kinase activity • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • kinase activity • RNA polymerase II core promoter proximal region sequence-specific DNA binding • protein binding • protein tyrosine kinase activity • receptor binding • ATP binding • RNA polymerase II regulatory region DNA binding • non-membrane spanning protein tyrosine kinase activity Cellular component • cytoplasm • membrane • extrinsic component of cytoplasmic side of plasma membrane • plasma membrane • nucleus Biological process • cell differentiation • regulation of transcription, DNA-templated • adaptive immune response • phosphorylation • tissue regeneration • transmembrane receptor protein tyrosine kinase signaling pathway • immune system process • regulation of transcription from RNA polymerase II promoter • cytokine production • positive regulation of interferon-gamma-mediated signaling pathway • positive regulation of interferon-gamma production • activation of phospholipase C activity • transcription, DNA-templated • protein phosphorylation • regulation of cell proliferation • peptidyl-tyrosine autophosphorylation • integrin-mediated signaling pathway • protein autophosphorylation • regulation of platelet activation • T cell receptor signaling pathway • positive regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7294	22165
Ensembl	ENSG00000074966	ENSMUSG00000054892
UniProt	P42681	P42682
RefSeq (mRNA)	NM_003328	NM_001122754 NM_001289494 NM_001289495 NM_013698
RefSeq (protein)	NP_003319	NP_001116226.1 NP_001276424.1 NP_001116226 NP_001276423 NP_001276424 NP_038726
Location (UCSC)	Chr 4: 48.07 – 48.13 Mb	Chr 5: 72.7 – 72.75 Mb
PubMed search

2DM0

7294

22165

ENSG00000074966

ENSMUSG00000054892

P42681

P42682

NM_003328

NM_001122754
NM_001289494
NM_001289495
NM_013698

NP_003319

NP_038726

Tyrosine-protein kinase TXK is an enzyme that in humans is encoded by the TXK gene.

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