TYK2

TYK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LXN, 3LXP, 3NYX, 3NZ0, 3ZON, 4GFO, 4GIH, 4GII, 4GJ2, 4GJ3, 4GVJ, 4OLI, 4PO6, 4PY1, 4WOV, 5C01, 5C03, 5F20, 5F1Z
Identifiers
Aliases	TYK2, IMD35, JTK1, tyrosine kinase 2, Non-receptor tyrosine-protein kinase
External IDs	MGI: 1929470 HomoloGene: 20712 GeneCards: TYK2
Genetically Related Diseases
rheumatoid arthritis, type 1 diabetes mellitus, psoriasis
Targeted by Drug
ruxolitinib
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • type 1 angiotensin receptor binding • growth hormone receptor binding • kinase activity • protein binding • protein tyrosine kinase activity • ATP binding • non-membrane spanning protein tyrosine kinase activity Cellular component • cytoplasm • cytosol • membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • cytoskeleton • nucleus Biological process • cell differentiation • intracellular signal transduction • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • protein phosphorylation • regulation of type I interferon-mediated signaling pathway • regulation of cell proliferation • type I interferon signaling pathway • peptidyl-tyrosine autophosphorylation • innate immune response • cell migration Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7297	54721
Ensembl	ENSG00000105397	ENSMUSG00000032175
UniProt	P29597	Q9R117
RefSeq (mRNA)	NM_003331	NM_001205312 NM_018793
RefSeq (protein)	NP_003322	n/a
Location (UCSC)	Chr 19: 10.35 – 10.38 Mb	Chr 9: 21.1 – 21.13 Mb
PubMed search

3LXN, 3LXP, 3NYX, 3NZ0, 3ZON, 4GFO, 4GIH, 4GII, 4GJ2, 4GJ3, 4GVJ, 4OLI, 4PO6, 4PY1, 4WOV, 5C01, 5C03, 5F20, 5F1Z

7297

54721

ENSG00000105397

ENSMUSG00000032175

P29597

...
Wikipedia