Thrombopoietin receptor

MPL
Identifiers
Aliases	MPL, C-CD110, MPLV, THCYT2, TPOR, MPL proto-oncogene, thrombopoietin receptor
External IDs	MGI: 97076 HomoloGene: 7845 GeneCards: MPL
Gene location (Human) Chr. Chromosome 1 (human) Band 1p34.2 Start 43,337,849 bp End 43,352,772 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 D2.1|4 54.61 cM Start 118,442,415 bp End 118,457,513 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • cytokine receptor activity • protein binding • transmembrane signaling receptor activity • thrombopoietin receptor activity Cellular component • integral component of membrane • cell surface • plasma membrane • Golgi apparatus • integral component of plasma membrane • membrane Biological process • cell surface receptor signaling pathway • cell proliferation • cytokine-mediated signaling pathway • thrombopoietin-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4352	17480
Ensembl	ENSG00000117400	ENSMUSG00000006389
UniProt	P40238	Q08351
RefSeq (mRNA)	NM_005373	NM_001122949 NM_001285496 NM_001285497 NM_010823
RefSeq (protein)	NP_005364	NP_001116421 NP_001272425 NP_001272426 NP_034953
Location (UCSC)	Chr 1: 43.34 – 43.35 Mb	Chr 1: 118.44 – 118.46 Mb
PubMed search

4352

17480

ENSG00000117400

ENSMUSG00000006389

P40238

Q08351

NM_005373

NM_001122949
NM_001285496
NM_001285497
NM_010823

NP_005364

NP_001116421
NP_001272425
NP_001272426
NP_034953

The thrombopoietin receptor also known as the myeloproliferative leukemia protein or CD110 (Cluster of Differentiation 110) is a protein that in humans is encoded by the MPL (myeloproliferative leukemia virus) oncogene.

In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation.

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Wikipedia