Tissue factor pathway inhibitor

TFPI
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4DTG, 1ADZ, 1IRH, 1TFX, 4BQD
Identifiers
Aliases	TFPI, EPI, LACI, TFI, TFPI1, tissue factor pathway inhibitor
External IDs	OMIM: 152310 MGI: 1095418 HomoloGene: 4579 GeneCards: TFPI
Gene ontology Molecular function • peptidase inhibitor activity • endopeptidase inhibitor activity • serine-type endopeptidase inhibitor activity Cellular component • organelle membrane • extracellular region • cell surface • anchored component of membrane • plasma membrane • endoplasmic reticulum • membrane • intracellular membrane-bounded organelle • extracellular space Biological process • hemostasis • blood coagulation, extrinsic pathway • negative regulation of peptidase activity • blood coagulation • response to lipopolysaccharide • response to estradiol • cellular response to lipopolysaccharide • negative regulation of endopeptidase activity • cellular response to interleukin-1 Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7035	21788
Ensembl	ENSG00000003436	ENSMUSG00000027082
UniProt	P10646	O54819
RefSeq (mRNA)	NM_001032281 NM_006287 NM_001318941 NM_001329239 NM_001329240 NM_001329241	NM_001177319 NM_001177320 NM_011576
RefSeq (protein)	NP_001027452 NP_001305870 NP_001316168 NP_001316169 NP_001316170 NP_006278	NP_035706.1 NP_001170790 NP_001170791 NP_035706
Location (UCSC)	Chr 2: 187.46 – 187.57 Mb	Chr 2: 84.43 – 84.48 Mb
PubMed search

4DTG, 1ADZ, 1IRH, 1TFX, 4BQD

7035

21788

ENSG00000003436

ENSMUSG00000027082

P10646

O54819

NM_001329241

NM_001177319
NM_001177320
NM_011576

NP_006278

NP_035706.1
NP_001170790
NP_001170791
NP_035706

Tissue factor pathway inhibitor (or TFPI) is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa). While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa-tissue factor complex. TFPI contributes significantly to the inhibition of Xa in vivo, despite being present at concentrations of only 2.5 nM.

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