Tissue transglutaminase

TGM2

Tissue transglutaminase.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4PYG, 1KV3, 2Q3Z, 3LY6, 3S3J, 3S3P, 3S3S

Identifiers

TGM2, G-ALPHA-h, GNAH, HEL-S-45, TG2, TGC, TG(C), transglutaminase 2

External IDs

OMIM: 190196 MGI: 98731 HomoloGene: 3391 GeneCards: TGM2

Gene ontology
Molecular function	• transferase activity • transferase activity, transferring acyl groups • protein-glutamine gamma-glutamyltransferase activity • protein binding • metal ion binding • GTP binding • protein domain specific binding
Cellular component	• cytoplasm • intrinsic component of plasma membrane • cytosol • extracellular exosome • focal adhesion • mitochondrion • endoplasmic reticulum • plasma membrane • extracellular matrix
Biological process	• apoptotic cell clearance • phospholipase C-activating G-protein coupled receptor signaling pathway • salivary gland cavitation • negative regulation of endoplasmic reticulum calcium ion concentration • positive regulation of mitochondrial calcium ion concentration • peptide cross-linking • positive regulation of cell adhesion • branching involved in salivary gland morphogenesis • positive regulation of inflammatory response • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway • isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine • positive regulation of apoptotic process • protein homooligomerization • positive regulation of smooth muscle cell proliferation • blood vessel remodeling
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE TGM2 211003 x at fs.png

PBB GE TGM2 211573 x at fs.png

PBB GE TGM2 201042 at fs.png

More reference expression data

Orthologs

Species

Human

Mouse


7052


21817


ENSG00000198959


ENSMUSG00000037820


P21980


P21981

RefSeq (mRNA)


NM_004613 NM_198951 NM_001323316 NM_001323317 NM_001323318


NM_009373

RefSeq (protein)


NP_001310245 NP_001310246 NP_001310247 NP_004604 NP_945189


NP_033399.1 NP_033399

Location (UCSC)

Chr 20: 38.13 – 38.17 Mb

Chr 2: 158.12 – 158.15 Mb

PubMed search

Protein-glutamine gamma-glutamyltransferase

Identifiers

Databases

metabolic pathway

PDB structures

RCSB PDB PDBe PDBsum

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NCBI	proteins

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PMC	articles
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NCBI	proteins

4PYG, 1KV3, 2Q3Z, 3LY6, 3S3J, 3S3P, 3S3S

ENSG00000198959

ENSMUSG00000037820

NM_004613
NM_198951
NM_001323316
NM_001323317
NM_001323318

NP_001310245
NP_001310246
NP_001310247
NP_004604
NP_945189

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Wikipedia

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