Topoisomerase I

TOP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A31, 1A35, 1A36, 1EJ9, 1K4S, 1K4T, 1LPQ, 1NH3, 1R49, 1RR8, 1RRJ, 1SC7, 1SEU, 1T8I, 1TL8
Identifiers
Aliases	TOP1, TOPI, topoisomerase (DNA) I
External IDs	MGI: 98788 HomoloGene: 2467 GeneCards: TOP1
Gene ontology Molecular function • DNA topoisomerase type I activity • chromatin binding • isomerase activity • DNA topoisomerase activity • core promoter sequence-specific DNA binding • protein binding • RNA binding • DNA binding • double-stranded DNA binding • single-stranded DNA binding • protein serine/threonine kinase activity • ATP binding • protein domain specific binding • supercoiled DNA binding Cellular component • cytoplasm • perikaryon • P-body • replication fork protection complex • chromosome • nuclear chromosome • nucleus • fibrillar center • nucleoplasm • nucleolus • DNA topoisomerase complex (ATP-hydrolyzing) • protein-DNA complex Biological process • chromatin remodeling • embryonic cleavage • programmed cell death • phosphorylation • rhythmic process • chromosome segregation • protein sumoylation • circadian regulation of gene expression • DNA replication • circadian rhythm • viral process • response to drug • DNA topological change • peptidyl-serine phosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7150	21969
Ensembl	ENSG00000198900	ENSMUSG00000070544
UniProt	P11387	Q04750
RefSeq (mRNA)	NM_003286	NM_009408
RefSeq (protein)	NP_003277	NP_033434
Location (UCSC)	Chr 20: 41.03 – 41.12 Mb	Chr 2: 160.65 – 160.72 Mb
PubMed search

1A31, 1A35, 1A36, 1EJ9, 1K4S, 1K4T, 1LPQ, 1NH3, 1R49, 1RR8, 1RRJ, 1SC7, 1SEU, 1T8I, 1TL8

7150

21969

ENSG00000198900

ENSMUSG00000070544

P11387

Q04750

NM_003286

NM_009408

...
Wikipedia