Transcription factor 2

HNF1B

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2DA6, 2H8R

Identifiers

Aliases

HNF1B, FJHN, HNF-1B, HNF1beta, HNF2, HPC11, LF-B3, LFB3, MODY5, TCF-2, TCF2, VHNF1, HNF-1-beta, HNF1 homeobox B

External IDs

MGI: 98505 HomoloGene: 396 GeneCards: HNF1B

Gene location (Human)

Chr.	Chromosome 17 (human)

Band	17q12	Start	37,686,432 bp
Band	17q12	End	37,745,247 bp

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)

Band	11 C\|11 51.23 cM	Start	83,850,063 bp
Band	11 C\|11 51.23 cM	End	83,905,819 bp

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• DNA binding • sequence-specific DNA binding • protein homodimerization activity • transcription factor activity, sequence-specific DNA binding • protein complex binding • core promoter proximal region DNA binding • protein binding • protein heterodimerization activity • transcription regulatory region DNA binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • RNA polymerase II regulatory region sequence-specific DNA binding
Cellular component	• transcription factor complex • nucleoplasm • nucleus
Biological process	• Notch signaling pathway • pronephros development • mesonephric tubule development • endoderm development • regulation of transcription, DNA-templated • response to organic cyclic compound • mesonephric duct development • endodermal cell fate specification • kidney development • mesonephric duct formation • ureteric bud elongation • protein-DNA complex assembly • negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis • hindbrain development • hepatocyte differentiation • epithelial cell proliferation • insulin secretion • negative regulation of apoptotic process • negative regulation of transcription from RNA polymerase II promoter • response to glucose • positive regulation of transcription initiation from RNA polymerase II promoter • nephric duct formation • circadian regulation of gene expression • transcription, DNA-templated • regulation of branch elongation involved in ureteric bud branching • negative regulation of mesenchymal cell apoptotic process involved in metanephros development • epithelium development • nephric duct development • genitalia development • pronephric nephron tubule development • positive regulation of transcription, DNA-templated • hepatoblast differentiation • regulation of Wnt signaling pathway • positive regulation of gene expression • inner cell mass cell differentiation • embryonic morphogenesis • kidney morphogenesis • embryonic digestive tract morphogenesis • liver development • regulation of endodermal cell fate specification • branching morphogenesis of an epithelial tube • response to carbohydrate • response to drug • regulation of pronephros size • anterior/posterior pattern specification • positive regulation of transcription from RNA polymerase II promoter • endocrine pancreas development
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6928


21410

Ensembl


ENSG00000276194 ENSG00000275410


ENSMUSG00000020679

UniProt


P35680


P27889

RefSeq (mRNA)


NM_000458 NM_001165923 NM_001304286 NM_006481


NM_001291268 NM_001291269 NM_009330

RefSeq (protein)


NP_000449 NP_001159395 NP_001291215 NP_001159395.1


NP_001278197 NP_001278198 NP_033356

Location (UCSC)

Chr 17: 37.69 – 37.75 Mb

Chr 17: 83.85 – 83.91 Mb

PubMed search

2DA6, 2H8R

6928

21410

ENSG00000276194
ENSG00000275410

ENSMUSG00000020679

P35680

P27889

NM_000458
NM_001165923
NM_001304286
NM_006481

NM_001291268
NM_001291269
NM_009330

NP_000449
NP_001159395
NP_001291215
NP_001159395.1

NP_001278197
NP_001278198
NP_033356

...
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