Transcription factor II E
| general transcription factor IIE, polypeptide 1, alpha 56kDa | |
|---|---|
| Identifiers | |
| Symbol | GTF2E1 |
| Alt. symbols | TF2E1 |
| Entrez | 2960 |
| HUGO | 4650 |
| OMIM | 189962 |
| RefSeq | NM_005513 |
| UniProt | P29083 |
| Other data | |
| Locus | Chr. 3 q21-q24 |
| general transcription factor IIE, polypeptide 2, beta 34kDa | |
|---|---|
| Identifiers | |
| Symbol | GTF2E2 |
| Alt. symbols | TF2E2 |
| Entrez | 2961 |
| HUGO | 4651 |
| OMIM | 189964 |
| RefSeq | NM_002095 |
| UniProt | P29084 |
| Other data | |
| Locus | Chr. 8 p12 |
Transcription factor II E (TFIIE) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. It is a tetramer of two alpha and two beta chains and interacts with TAF6/TAFII80, ATF7IP, and varicella-zoster virus IE63 protein.
TFIIE recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. Transcription Factor II E is encoded by the GTF2E1 and GTF2E2 genes. TFIIE is thought to be involved in DNA melting at the promoter: it contains a zinc ribbon motif that can bind single stranded DNA.
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