Tryptophan 2,3-dioxygenase

TDO2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4PW8
Identifiers
Aliases	TDO2, TDO, TO, TPH2, TRPO, tryptophan 2,3-dioxygenase
External IDs	MGI: 1928486 HomoloGene: 4132 GeneCards: TDO2
Gene ontology Molecular function • oxygen binding • oxidoreductase activity • protein binding • dioxygenase activity • amino acid binding • metal ion binding • identical protein binding • tryptophan 2,3-dioxygenase activity • heme binding Cellular component • cytosol Biological process • tryptophan catabolic process • tryptophan catabolic process to acetyl-CoA • tryptophan metabolic process • oxidation-reduction process • tryptophan catabolic process to kynurenine • protein homotetramerization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6999	56720
Ensembl	n/a	ENSMUSG00000028011
UniProt	P48775	P48776
RefSeq (mRNA)	NM_005651	NM_019911
RefSeq (protein)	NP_005642	NP_064295.2 NP_064295
Location (UCSC)	Chr 4: 155.85 – 155.92 Mb	Chr 3: 81.96 – 81.98 Mb
PubMed search

Tryptophan 2,3-dioxygenase
Crystal structure of the tryptophan 2,3-dioxygenase from xanthomonas campestris
Identifiers
EC number	1.13.11.11
CAS number	9014-51-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

4PW8

6999

56720

n/a

ENSMUSG00000028011

P48775

P48776

NM_005651

NM_019911

NP_005642

NP_064295.2
NP_064295

In enzymology, tryptophan 2,3-dioxygenase (EC 1.13.11.11) is a heme enzyme that catalyzes the oxidation of L-tryptophan (L-Trp) to N-formyl-L-kynurenine, as the first and rate-limiting step of the kynurenine pathway.

Tryptophan 2,3-dioxygenase plays a central role in the physiological regulation of tryptophan flux in the human body, as part of the overall biological process of tryptophan metabolism. TDO catalyses the first and rate-limiting step of tryptophan degradation along the kynurenine pathway and thereby regulates systemic tryptophan levels. In humans, tryptophan 2,3-dioxygenase is encoded by the TDO2 gene.