U-50488

U-50488
Identifiers


IUPAC name 2-(3,4-dichlorophenyl)-N-methyl-N-[(1R,2R)-2-pyrrolidin-1-ylcyclohexyl]acetamide
CAS Number	67198-13-4^Y
PubChem CID	3036289
IUPHAR/BPS	1652
ChemSpider	2300345^N
ChEBI	CHEBI:73358^N
ChEMBL	CHEMBL441765^N
Chemical and physical data
Formula	C₁₉H₂₆Cl₂N₂O
Molar mass	369.329 g/mol
3D model (Jmol)	Interactive image
SMILES CN([C@@H]1CCCC[C@H]1N2CCCC2)C(=O)CC3=CC(=C(C=C3)Cl)Cl
InChI InChI=1S/C19H26Cl2N2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23/h8-9,12,17-18H,2-7,10-11,13H2,1H3/t17-,18-/m1/s1^N Key:VQLPLYSROCPWFF-QZTJIDSGSA-N^N
^NY (what is this?)

U-50488 is a drug which acts as a highly selective κ-opioid agonist, but without any μ-opioid antagonist effects. It has analgesic, diuretic and antitussive effects, and reverses the memory impairment produced by anticholinergic drugs. U-50488 was one of the first selective kappa agonists invented and research on its derivatives has led to the development of a large family of related compounds.

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