| U.S. Route 22 | ||||
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| Route information | ||||
| Maintained by PennDOT & DRJTBC | ||||
| Length: | 337.60 mi (543.31 km) | |||
| Existed: | 1926 – present | |||
| Major junctions | ||||
| West end: |
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| East end: |
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| Location | ||||
| Counties: | Washington, Allegheny, Westmoreland, Indiana, Cambria, Blair, Huntingdon, Mifflin, Juniata, Perry, Dauphin, Lebanon, Berks, Lehigh, Northampton | |||
| Highway system | ||||
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I-376 between Robinson Township and Monroeville
I-79 near Carnegie![]()
I-279 / US 19 in Pittsburgh![]()
I-76 / Penna Turnpike in Monroeville![]()
I-99 / US 220 in Duncansville![]()
I-81 / US 322 near Harrisburg
I-83 in Lower Paxton Township
I-78 from Fredericksburg to Kuhnsville