| U.S. Route 78 | |
|---|---|
| Highway system | |
|  U.S. Route 78 Business | |
|---|---|
| Location: | Red Banks, Mississippi | 
|  U.S. Route 78 Business | |
|---|---|
| Location: | Hickory Flat, Mississippi | 
|  U.S. Route 78 Alternate | |
|---|---|
| Location: | Hamilton–Graysville, Alabama | 
|  U.S. Route 78 Alternate | |
|---|---|
| Location: | Carbon Hill–Jasper, Alabama | 
|  U.S. Route 78 Alternate | |
|---|---|
| Location: | Birmingham–Irondale, Alabama | 
|  U.S. Route 78 Truck | |
|---|---|
| Location: | Birmingham, Alabama | 
|  U.S. Route 78 Truck | |
|---|---|
| Location: | Leeds, Alabama | 
|  U.S. Route 78 Business | |
|---|---|
| Location: | Anniston, Alabama | 
| U.S. Highway 78N | |
|---|---|
| Location: | Heflin, Alabama–Villa Rica, Georgia | 
| Existed: | 1927–November 1934 | 
At least 15 special routes of U.S. Route 78 have existed.